Seroatlas · Human Serome Atlas

ALPK1

Alpha-protein kinase 1

Also known as: ALPK1_HUMAN, FLJ22670, KIAA1527, Lak

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96QP1
Gene: ALPK1
Ensembl: ENSG00000073331
Chromosome: 4
Canonical length: 1244 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Centrosome,Basal body

OverviewNCBI Gene

This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

1244 residues, UniProt reviewed canonical sequence.

>Q96QP1|ALPK1
     1  MNNQKVVAVL LQECKQVLDQ LLLEAPDVSE EDKSEDQRCR ALLPSELRTL IQEAKEMKWP
    61  FVPEKWQYKQ AVGPEDKTNL KDVIGAGLQQ LLASLRASIL ARDCAAAAAI VFLVDRFLYG
   121  LDVSGKLLQV AKGLHKLQPA TPIAPQVVIR QARISVNSGK LLKAEYILSS LISNNGATGT
   181  WLYRNESDKV LVQSVCIQIR GQILQKLGMW YEAAELIWAS IVGYLALPQP DKKGLSTSLG
   241  ILADIFVSMS KNDYEKFKNN PQINLSLLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLTAV
   301  NIRGTCLLSY SSSNDCPPEL KNLHLCEAKE AFEIGLLTKR DDEPVTGKQE LHSFVKAAFG
   361  LTTVHRRLHG ETGTVHAASQ LCKEAMGKLY NFSTSSRSQD REALSQEVMS VIAQVKEHLQ
   421  VQSFSNVDDR SYVPESFECR LDKLILHGQG DFQKILDTYS QHHTSVCEVF ESDCGNNKNE
   481  QKDAKTGVCI TALKTEIKNI DTVSTTQEKP HCQRDTGISS SLMGKNVQRE LRRGGRRNWT
   541  HSDAFRVSLD QDVETETEPS DYSNGEGAVF NKSLSGSQTS SAWSNLSGFS SSASWEEVNY
   601  HVDDRSARKE PGKEHLVDTQ CSTALSEELE NDREGRAMHS LHSQLHDLSL QEPNNDNLEP
   661  SQNQPQQQMP LTPFSPHNTP GIFLAPGAGL LEGAPEGIQE VRNMGPRNTS AHSRPSYRSA
   721  SWSSDSGRPK NMGTHPSVQK EEAFEIIVEF PETNCDVKDR QGKEQGEEIS ERGAGPTFKA
   781  SPSWVDPEGE TAESTEDAPL DFHRVLHNSL GNISMLPCSS FTPNWPVQNP DSRKSGGPVA
   841  EQGIDPDAST VDEEGQLLDS MDVPCTNGHG SHRLCILRQP PGQRAETPNS SVSGNILFPV
   901  LSEDCTTTEE GNQPGNMLNC SQNSSSSSVW WLKSPAFSSG SSEGDSPWSY LNSSGSSWVS
   961  LPGKMRKEIL EARTLQPDDF EKLLAGVRHD WLFQRLENTG VFKPSQLHRA HSALLLKYSK
  1021  KSELWTAQET IVYLGDYLTV KKKGRQRNAF WVHHLHQEEI LGRYVGKDYK EQKGLWHHFT
  1081  DVERQMTAQH YVTEFNKRLY EQNIPTQIFY IPSTILLILE DKTIKGCISV EPYILGEFVK
  1141  LSNNTKVVKT EYKATEYGLA YGHFSYEFSN HRDVVVDLQG WVTGNGKGLI YLTDPQIHSV
  1201  DQKVFTTNFG KRGIFYFFNN QHVECNEICH RLSLTRPSME KPCT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALPK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 9.7 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 9.7 nTPM
spleen: 8.6 nTPM
skin: 6.5 nTPM
urinary bladder: 6.2 nTPM
tonsil: 5.7 nTPM
kidney: 5.4 nTPM

Single-cell type

neutrophils: 1,466 nCPM
neutrophil progenitors: 733 nCPM
microglia: 206 nCPM
pituicytes/fscs: 137 nCPM
hematopoietic stem cells: 126 nCPM
choroid plexus epithelial cells: 124 nCPM

Immune cell

neutrophil: 19 nTPM
intermediate monocyte: 4.7 nTPM
classical monocyte: 3.7 nTPM
myeloid DC: 3.7 nTPM
non-classical monocyte: 2.2 nTPM
eosinophil: 1.7 nTPM

Brain region

hippocampal formation: 14 nTPM
choroid plexus: 12 nTPM
cerebral cortex: 10 nTPM
basal ganglia: 9.3 nTPM
white matter: 9.2 nTPM
medulla oblongata: 9.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ALPK1.

Disease | AllUniProt

Conditions ALPK1 is implicated in, by any mechanism.

Retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome (ROSAH) MIM:614979

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 954 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome
ALPK1-related disorder
Inborn genetic diseases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: -0.28
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Alpha-type protein kinase, alpha-kinase domain
Protein kinase-like domain superfamily
Alpha-kinase family
Alpha-protein kinase 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALPK1 as an antibody target. Whether an autoantibody or antibody against ALPK1 could matter depends on whether native ALPK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALPK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ALPK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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