Beta-1,4-galactosyltransferase
IPR003859
Definition
Beta-1,4-galactosyltransferase is responsible for catalysing the transfer of galactose onto proteins or lipids PMID:10580128. Studies on C.elegans have shown that the enzyme is required for susceptibility to pore-forming crystal toxins, together with glycosyltransferase genes bre-1, bre-2, bre-3 and bre-5 PMID:12944392. In mammals, the protein is found in long and short forms. The short form is preferentially located in the golgi complex PMID:1714903, where it catalyses the production of lactose in the lactating mammary gland; it may also be responsible for the synthesis of complex-type N-linked oligosaccharides of various glycoproteins, as well as the carbohydrate moieties of glycolipids. The short form is preferentially targeted to the plasma membrane of many cell types PMID:1714903, where it functions as a recognition molecule during various cell-cell and cell-matrix interactions, by binding to specific oligosaccharide ligands on opposing cells, or in the extracellular matrix. This entry also includes other members of the glycosyltransferase 7 family, such as xylosylprotein 4-beta-galactosyltransferase and beta-N-acetyl-D-glucosaminide beta-1,4-N-acetylglucosaminyl-transferase.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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