OAR domain
IPR003654
Definition
This 14 amino acid motif has been identified within the C-terminal region of several paired-like homeodomain (HD) containing proteins [[cite:PMID:8944018], [cite:PMID:9466998]]. It was named OAR domain after the initials of otp, aristaless, and rax PMID:9096350. Although it has been proposed that this domain could be important for transactivation and be involved in protein-protein interactions or DNA binding [[cite:PMID:9096350], [cite:PMID:9140395]], its function is not yet known. Some proteins known to contain a OAR domain include human RIEG, defects in which are the cause of Rieger syndrome PMID:8944018; human OG12X and Mus musculus (Mouse) Og12x, whose function is not yet known PMID:9466998; vertebrate Rax, which plays a role in the proliferation and/or differentiation of retinal cells PMID:9096350; Drosophila DRX, which appears to be important in brain development PMID:9482887; and human SHOX, encoded by the short stature homeobox-containing gene.
16 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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