Seroatlas · Human Serome Atlas

OTP

Homeobox protein orthopedia

Also known as: OTP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5XKR4
Gene: OTP
Ensembl: ENSG00000171540
Chromosome: 5
Canonical length: 325 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Nuclear bodies

OverviewNCBI Gene

This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q5XKR4|OTP
     1  MLSHADLLDA RLGMKDAAEL LGHREAVKCR LGVGGSDPGG HPGDLAPNSD PVEGATLLPG
    61  EDITTVGSTP ASLAVSAKDP DKQPGPQGGP NPSQAGQQQG QQKQKRHRTR FTPAQLNELE
   121  RSFAKTHYPD IFMREELALR IGLTESRVQV WFQNRRAKWK KRKKTTNVFR APGTLLPTPG
   181  LPQFPSAAAA AAAAMGDSLC SFHANDTRWA AAAMPGVSQL PLPPALGRQQ AMAQSLSQCS
   241  LAAGPPPNSM GLSNSLAGSN GAGLQSHLYQ PAFPGMVPAS LPGPSNVSGS PQLCSSPDSS
   301  DVWRGTSIAS LRRKALEHTV SMSFT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OTP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 17 nTPM
testis: 0.2 nTPM
lung: 0.1 nTPM
midbrain: 0.1 nTPM
spinal cord: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

other brain neurons: 20 nCPM
early primary spermatocytes: 6.4 nCPM
kupffer cells: 1 nCPM
brain excitatory neurons: 0.9 nCPM
differentiating spermatogonia: 0.9 nCPM
mucous neck cells: 0.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 62 nTPM
medulla oblongata: 19 nTPM
pons: 14 nTPM
basal ganglia: 6 nTPM
midbrain: 3.7 nTPM
thalamus: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.74
gnomAD missense Z: 1.02
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OTP as an antibody target. Whether an autoantibody or antibody against OTP could matter depends on whether native OTP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OTP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OTP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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