Seroatlas · Human Serome Atlas

PRRX2

Paired mesoderm homeobox protein 2

Also known as: PMX2, PRRX2_HUMAN, PRX2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99811
Gene: PRRX2
Ensembl: ENSG00000167157
Chromosome: 9
Canonical length: 253 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>Q99811|PRRX2
     1  MDSAAAAFAL DKPALGPGPP PPPPALGPGD CAQARKNFSV SHLLDLEEVA AAGRLAARPG
    61  ARAEAREGAA REPSGGSSGS EAAPQDGECP SPGRGSAAKR KKKQRRNRTT FNSSQLQALE
   121  RVFERTHYPD AFVREELARR VNLSEARVQV WFQNRRAKFR RNERAMLASR SASLLKSYSQ
   181  EAAIEQPVAP RPTALSPDYL SWTASSPYST VPPYSPGSSG PATPGVNMAN SIASLRLKAK
   241  EFSLHHSQVP TVN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRRX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 52 nTPM
skin: 25 nTPM
cervix: 20 nTPM
vagina: 18 nTPM
adipose tissue: 14 nTPM
prostate: 13 nTPM

Single-cell type

early spermatids: 91 nCPM
fibroblasts: 77 nCPM
endometrial secretory cells: 73 nCPM
late primary spermatocytes: 45 nCPM
vascular smooth muscle cells: 39 nCPM
pericytes: 38 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 1.8 nTPM
choroid plexus: 1.5 nTPM
pons: 0.7 nTPM
cerebral cortex: 0.6 nTPM
hippocampal formation: 0.6 nTPM
amygdala: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0.14
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRRX2 as an antibody target. Whether an autoantibody or antibody against PRRX2 could matter depends on whether native PRRX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRRX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRRX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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