Interleukin-1 receptor antagonist/Interleukin-36
IPR003297
Definition
This entry represents IL-1RA and Interleukin-36 cytokines. Interleukin-1 receptor antagonist (IL-1RA) binds to the IL-1 receptor, blocking the effects of Interleukin-1 alpha and interleukin-1 beta (IL-1A and IL-1B), whilst eliciting no response of its own. From sequence comparisons, it seems to have arisen by gene duplication before IL-1 diverged into IL-1A and IL-1B, as it has features of both PMID:1828896. It seems likely to have the same fold as IL-1A and IL-1B. IL-1A and IL-1B are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis PMID:2969618. Interleukin-36 cytokines constitute a novel cluster of cytokines with structural and functional similarities to IL-1 PMID:23029241. Previously designated as interleukin-1 family members 5 - 10 (IL-1F5 to IL-1F10), they have recently been reclassified according to an updated cytokine nomenclature scheme PMID:20959797. Family members include: interleukin-36 alpha, beta and gamma (previously IL-1F6, IL-1F8 and IL-1F9, respectively), which are pro-inflammatory and signal through IL-1Rrp2 and IL-1RAcP PMID:14734551. interleukin-36 receptor antagonist (previously IL-1F5), which binds IL-1Rrp2, acting as an antagonist for interleukins signalling via this route PMID:17908936. interleukin-37 (IL-1F7), which exerts anti-inflammatory actions by suppressing production of pro-inflammatory cytokines PMID:20935647. IL-1F10, whose function is unknown.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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