IL37

Protein identityUniProt · HPA

UniProt accession

Q9NZH6

Gene

IL37

Ensembl

ENSG00000125571

Chromosome

2

Canonical length

218 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Vesicles,Cytosol

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

218 residues, UniProt reviewed canonical sequence.

>Q9NZH6|IL37
     1  MSFVGENSGV KMGSEDWEKD EPQCCLEDPA GSPLEPGPSL PTMNFVHTSP KVKNLNPKKF
    61  SIHDQDHKVL VLDSGNLIAV PDKNYIRPEI FFALASSLSS ASAEKGSPIL LGVSKGEFCL
   121  YCDKDKGQSH PSLQLKKEKL MKLAAQKESA RRPFIFYRAQ VGSWNMLESA AHPGWFICTS
   181  CNCNEPVGVT DKFENRKHIE FSFQPVCKAE MSPSEVSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

114 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL37.

Disease | AllUniProt

Conditions IL37 is implicated in, by any mechanism.

• Inflammatory bowel disease 31, autosomal recessive (IBD31) MIM:619398

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 35 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive
• Inflammatory bowel disease

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.73

gnomAD pLI

0

gnomAD missense Z

-0.04

DepMap mean gene effect

-0.11

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to lipopolysaccharide
• cytokine-mediated signaling pathway
• immune response
• inflammatory response
• negative regulation of interleukin-6 production
• negative regulation of tumor necrosis factor production
• regulation of inflammatory response

Molecular functions

• cytokine activity
• identical protein binding
• interleukin-1 receptor binding

Cellular components

• cytosol
• extracellular region
• extracellular space
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Interleukin-1 family
• Interleukin-1 receptor antagonist/Interleukin-36
• Cytokine IL1/FGF
• Interleukin-1 / 18

KeywordsUniProt

• Cytokine
• Cytoplasm
• Nucleus
• Secreted

InteractionsUniProt · HPA

Protein binding partners of IL37 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SMAD3