Seroatlas · Human Serome Atlas

IL1F10

Interleukin-1 family member 10

Also known as: FKSG75, IL-1F10, IL-1HY2, IL1-theta, IL1FA_HUMAN, MGC11983, MGC119832, MGC119833

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWZ1
Gene: IL1F10
Ensembl: ENSG00000136697
Chromosome: 2
Canonical length: 152 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

152 residues, UniProt reviewed canonical sequence.

>Q8WWZ1|IL1F10
     1  MCSLPMARYY IIKYADQKAL YTRDGQLLVG DPVADNCCAE KICILPNRGL ARTKVPIFLG
    61  IQGGSRCLAC VETEEGPSLQ LEDVNIEELY KGGEEATRFT FFQSSSGSAF RLEAAAWPGW
   121  FLCGPAEPQQ PVQLTKESEP SARTKFYFEQ SW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL1F10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

skin: 12 nTPM
tonsil: 2.6 nTPM
breast: 0.4 nTPM
cervix: 0.1 nTPM
esophagus: 0.1 nTPM
thymus: 0.1 nTPM

Single-cell type

esophageal apical cells: 2.4 nCPM
ocular epithelial cells: 0.5 nCPM
early spermatids: 0.4 nCPM
esophageal suprabasal cells: 0.3 nCPM
mesothelial cells: 0.3 nCPM
migrating cytotrophoblasts: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -0.28
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL1F10 as an antibody target. Whether an autoantibody or antibody against IL1F10 could matter depends on whether native IL1F10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL1F10 is annotated as secreted, so native IL1F10 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL1F10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...