LONRF2

Protein identityUniProt · HPA

UniProt accession

Q1L5Z9

Gene

LONRF2

Ensembl

ENSG00000170500

Chromosome

2

Canonical length

754 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Predicted to enable misfolded protein binding activity; ribonucleoprotein complex binding activity; and ubiquitin protein ligase activity. Predicted to act upstream of or within several processes, including motor behavior; neuron differentiation; and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

754 residues, UniProt reviewed canonical sequence.

>Q1L5Z9|LONRF2
     1  MSPEPVPPPP PPQCPGCDRA EPIAQRLEEG DEAFRAGDYE MAAELFRSML AGLAQPDRGL
    61  CLRLGDALAR AGRLPEALGA FRGAARLGAL RPEELEELAG GLVRAVGLRD RPLSAENPGG
   121  EPEAPGEGGP APEPRAPRDL LGCPRCRRLL HKPVTLPCGL TVCKRCVEPG PARPQVRRVN
   181  VVLSGLLEKC FPAECRLRRL AGQARSLQRQ QQPEAALLRC DQALELAPDD NSLLLLRAEL
   241  YLTMKNYEQA LQDASAACQN EPLLIKGHQV KAQALSGLGR SKEVLKEFLY CLALNPECNS
   301  VKKEAQKVMC EVLFSATANV HENLTSSIQS RLKAQGHSHM NAQALLEEGD AGSSENSSEK
   361  SDMLGNTNSS VLYFILGLHF EEDKKALESI LPTAPSAGLK RQFPDDVEDA PDLNAPGKIP
   421  KKDLSLQRSP NSETEESQGL SLDVTDFECA LCMRLLFEPV TTPCGHTFCL KCLERCLDHA
   481  PHCPLCKDKL SELLASRNFN ITVLAEELIF RYLPDELSDR KRIYDEEMSE LSNLTRDVPI
   541  FVCAMAFPTV PCPLHVFEPR YRLMIRRCME TGTKRFGMCL SAEHAGLSEY GCMLEIKDVR
   601  TFPDGSSVVD AIGISRFRVL SHRHRDGYNT ADIEYLEDEK VEGPEYEELA ALHDSVHQQS
   661  VSWFASLQDR MKEQILSHFG VMPDREPEPQ SNPSGPAWSW WILAVLPLER KAQLAILGMT
   721  SLKERLLAIR RILVIITRKM NSRQELANAR ERNN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LONRF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

41 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.62

gnomAD pLI

0

gnomAD missense Z

2.05

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• motor behavior
• negative regulation of neuron apoptotic process
• neuromuscular process
• neuron apoptotic process
• neuron projection development
• protein quality control for misfolded or incompletely synthesized proteins
• spinal cord motor neuron differentiation

Molecular functions

• misfolded protein binding
• ribonucleoprotein complex binding
• ubiquitin protein ligase activity
• zinc ion binding

Cellular components

• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, RING-type
• Lon protease, N-terminal domain
• Tetratricopeptide-like helical domain superfamily
• Zinc finger, RING/FYVE/PHD-type
• PUA-like superfamily
• Zinc finger, RING-type, conserved site
• Tetratricopeptide repeat
• Lon protease, N-terminal domain superfamily
• ATP-dependent protease La (LON) substrate-binding domain
• Tetratricopeptide repeat
• Zinc finger, C3HC4 type (RING finger)

KeywordsUniProt

• Metal-binding
• Repeat
• TPR repeat
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of LONRF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TARDBP