Seroatlas · Human Serome Atlas

LONRF3

LON peptidase N-terminal domain and RING finger protein 3

Also known as: FLJ22612, LONF3_HUMAN, RNF127

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q496Y0
Gene: LONRF3
Ensembl: ENSG00000175556
Chromosome: X
Canonical length: 759 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Multiple alternatively spliced transcript variants have been suggested, but their full length natures are not clear. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

759 residues, UniProt reviewed canonical sequence.

>Q496Y0|LONRF3
     1  MESVRIEQML SLPAEVSSDN LESAERGASA AQVDMGPHPK VAAEGPAPLP TREPEQEQSP
    61  GTSTPESKVL LTQADALASR GRIREALEVY RQLSERQQLV AEQLEQLVRC LAEKVPQGEA
   121  LAPAPPDEGS TASGTVAAEE TGAAAAAAAT EVWDGFKCRK CHGFLSDPVS LSCGHTFCKL
   181  CLERGRAADR RCALCGVKLS ALMVATGRAR GARRAGQQPP PPLRVNVVLS GLLGKLFPGP
   241  ARASQLRHEG NRLYRERQVE AALLKYNEAV KLAPNDHLLY SNRSQIYFTL ESHENALHDA
   301  EIACKLRPMG FKAHFRKAQA LATLGKVEEA LREFLYCVSL DGKNKRARCE AQRDNLELPH
   361  CSSQEEAAAR GDGSSLMDPA KVKGDGQQHH MKDQEEEEEK WDATSPKAAS SKTGKCQEKK
   421  RKHCQIESQE ETGMPNKASK QDPPTDQGDK PALSLPLASF DASDLECALC MRLFYEPVTT
   481  PCGHTFCLKC LERCLDHNAK CPLCKDGLSQ CLASRKYSKN VIMEELIAKF LPEELKERRK
   541  LYEEEMEELS NLNKNVPIFV CTMAYPTVPC PLHIFEPCYR LMIRRCIETG TRQFGMCLGD
   601  PVKGFAEYGC ILEIRNVQFF ADGRSVVDSI GKRRFRVLHQ SQRDGYNTAD IEYIEDQKVQ
   661  GEDCAELMGL HNCVYQQASL WFHSLKLSLK NRILNHFGPM PEKDADPQMN PNGPAWCWWM
   721  LAVLPLESRA QLPFLAMRSL KDRLNGIRRV LAFISRNQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LONRF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

liver: 12 nTPM
skeletal muscle: 9.1 nTPM
thyroid gland: 7.6 nTPM
pancreas: 6.6 nTPM
lung: 6 nTPM
salivary gland: 4.5 nTPM

Single-cell type

monocytes: 160 nCPM
epididymal basal cells: 143 nCPM
endometrial glandular cells: 136 nCPM
alveolar cells type 2: 133 nCPM
epididymal efferent duct absorptive cells: 105 nCPM
salivary acinar cells: 89 nCPM

Immune cell

MAIT T-cell: 3.8 nTPM
gdT-cell: 2.4 nTPM
memory CD4 T-cell: 1.1 nTPM
memory CD8 T-cell: 0.8 nTPM
naive CD8 T-cell: 0.8 nTPM
naive CD4 T-cell: 0.5 nTPM

Brain region

cerebellum: 17 nTPM
hippocampal formation: 11 nTPM
cerebral cortex: 9.5 nTPM
midbrain: 7.9 nTPM
thalamus: 7.9 nTPM
spinal cord: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.42
gnomAD missense Z: 1.27
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LONRF3 as an antibody target. Whether an autoantibody or antibody against LONRF3 could matter depends on whether native LONRF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LONRF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LONRF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...