Peptidase M20
IPR002933
Definition
This group of proteins contains the metallopeptidases and non-peptidase homologues (amidohydrolases) that belong to the MEROPS peptidase family M20 (clan MH) PMID:7674922. The peptidases of this clan have two catalytic zinc ions at the active site, bound by His/Asp, Asp, Glu, Asp/Glu and His. The catalysed reaction involves the release of an N-terminal amino acid, usually neutral or hydrophobic, from a polypeptide PMID:7674922. The peptidase M20 family has four subfamilies: M20A -type example, glutamate carboxypeptidase from Pseudomonas sp. RS16 ([swissprot:P06621]) M20B -type example, peptidase T from Escherichia coli ([swissprot:P29745]) M20C -type example, X-His dipeptidase from E. coli ([swissprot:P15288]) M20D -type example, carboxypeptidase Ss1 from Sulfolobus solfataricus ([swissprot:P80092]) Homologues from the family that are not peptidases include: Acetylornithine deacetylase, which releases an acetyl group and L-ornithine from N(2)-acetyl-L-ornithine PMID:10684608 N-acetyldiaminopimelate deacetylase, which catalyses the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate PMID:5411754 N-carbamoyl-L-amino-acid hydrolase, which converts D,L-5-monosubstituted hydantoins into D-or L-amino acids PMID:1732229 Aminoacylase-1, which hydrolyses N-acylated or N-acetylated amino acids PMID:12933810 Succinyl-diaminopimelate desuccinylase ([ec:3.5.1.18]), which catalyses the hydrolysis of N-succinyl-L,L-diaminopimelic acid, forming succinate and LL-2,6-diaminoheptanedioate (DAP, a component of bacterial cell walls) PMID:3276674
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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