Seroatlas · Human Serome Atlas

PM20D1

N-fatty-acyl-amino acid synthase/hydrolase PM20D1

Also known as: Cps1, FLJ32569, P20D1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6GTS8
Gene: PM20D1
Ensembl: ENSG00000162877
Chromosome: 1
Canonical length: 502 aa
Protein class: Enzymes, Predicted secreted proteins
Secretome location: Secreted to digestive system

OverviewNCBI Gene

Enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including amide biosynthetic process; amide catabolic process; and amino acid metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

502 residues, UniProt reviewed canonical sequence.

>Q6GTS8|PM20D1
     1  MAQRCVCVLA LVAMLLLVFP TVSRSMGPRS GEHQRASRIP SQFSKEERVA MKEALKGAIQ
    61  IPTVTFSSEK SNTTALAEFG KYIHKVFPTV VSTSFIQHEV VEEYSHLFTI QGSDPSLQPY
   121  LLMAHFDVVP APEEGWEVPP FSGLERDGII YGRGTLDDKN SVMALLQALE LLLIRKYIPR
   181  RSFFISLGHD EESSGTGAQR ISALLQSRGV QLAFIVDEGG FILDDFIPNF KKPIALIAVS
   241  EKGSMNLMLQ VNMTSGHSSA PPKETSIGIL AAAVSRLEQT PMPIIFGSGT VVTVLQQLAN
   301  EFPFPVNIIL SNPWLFEPLI SRFMERNPLT NAIIRTTTAL TIFKAGVKFN VIPPVAQATV
   361  NFRIHPGQTV QEVLELTKNI VADNRVQFHV LSAFDPLPVS PSDDKALGYQ LLRQTVQSVF
   421  PEVNITAPVT SIGNTDSRFF TNLTTGIYRF YPIYIQPEDF KRIHGVNEKI SVQAYETQVK
   481  FIFELIQNAD TDQEPVSHLH KL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PM20D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

pancreas: 74 nTPM
skin: 32 nTPM
kidney: 5.9 nTPM
stomach: 2.7 nTPM
urinary bladder: 2.1 nTPM
breast: 1.1 nTPM

Single-cell type

cardiomyocytes: 65 nCPM
retinal ganglion cells: 50 nCPM
pancreatic acinar cells: 43 nCPM
cone photoreceptor cells: 29 nCPM
retinal horizontal cells: 20 nCPM
epicardial cells: 14 nCPM

Immune cell

T-reg: 2.2 nTPM
memory CD8 T-cell: 1.3 nTPM
MAIT T-cell: 0.5 nTPM
basophil: 0.4 nTPM
eosinophil: 0.4 nTPM
memory CD4 T-cell: 0.4 nTPM

Brain region

choroid plexus: 4.7 nTPM
white matter: 2.9 nTPM
cerebral cortex: 2.8 nTPM
midbrain: 2.8 nTPM
pons: 2.8 nTPM
thalamus: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PM20D1 as an antibody target. Whether an autoantibody or antibody against PM20D1 could matter depends on whether native PM20D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PM20D1 is annotated as secreted, so native PM20D1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PM20D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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