Seroatlas · Human Serome Atlas

PM20D2

Xaa-Arg dipeptidase

Also known as: ACY1L2, bA63L7.3, P20D2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYS1
Gene: PM20D2
Ensembl: ENSG00000146281
Chromosome: 6
Canonical length: 436 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables dipeptidase activity and identical protein binding activity. Acts upstream of or within proteolysis and regulation of protein metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

436 residues, UniProt reviewed canonical sequence.

>Q8IYS1|PM20D2
     1  MRPGGERPVE GGACNGRSEL ELLKLRSAEC IDEAAERLGA LSRAIWSQPE LAYEEHHAHR
    61  VLTHFFEREP PAASWAVQPH YQLPTAFRAE WEPPEARAPS ATPRPLHLGF LCEYDALPGI
   121  GHACGHNLIA EVGAAAALGV RGALEGLPRP PPPVKVVVLG TPAEEDGGGK IDLIEAGAFT
   181  NLDVVFMAHP SQENAAYLPD MAEHDVTVKY YGKASHSASY PWEGLNALDA AVLAYNNLSV
   241  FRQQMKPTWR VHGIIKNGGV KPNIIPSYSE LIYYFRAPSM KELQVLTKKA EDCFRAAALA
   301  SGCTVEIKGG AHDYYNVLPN KSLWKAYMEN GRKLGIEFIS EDTMLNGPSG STDFGNVSFV
   361  VPGIHPYFHI GSNALNHTEQ YTEAAGSQEA QFYTLRTAKA LAMTALDVIF KPELLEGIRE
   421  DFKLKLQEEQ FVNAVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PM20D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 28 nTPM
prostate: 24 nTPM
tongue: 15 nTPM
blood vessel: 15 nTPM
ovary: 14 nTPM
retina: 13 nTPM

Single-cell type

thymic myoid cells: 241 nCPM
myonuclei: 203 nCPM
prostatic glandular cells: 83 nCPM
cardiomyocytes: 61 nCPM
smooth muscle cells: 59 nCPM
cone photoreceptor cells: 54 nCPM

Immune cell

NK-cell: 1.9 nTPM
memory B-cell: 1.5 nTPM
naive CD4 T-cell: 1.4 nTPM
memory CD8 T-cell: 1.3 nTPM
eosinophil: 1.2 nTPM
MAIT T-cell: 1.2 nTPM

Brain region

choroid plexus: 23 nTPM
cerebellum: 17 nTPM
hypothalamus: 15 nTPM
basal ganglia: 12 nTPM
medulla oblongata: 12 nTPM
amygdala: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: 0.98
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

Peptidase M20
Peptidase M20, dimerisation domain
Bacterial exopeptidase dimerisation domain
Peptidase family M20/M25/M40
Peptidase dimerisation domain
Xaa-Arg dipeptidase
Peptidase M20/M20A family hydrolases

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PM20D2 as an antibody target. Whether an autoantibody or antibody against PM20D2 could matter depends on whether native PM20D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PM20D2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PM20D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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