Seroatlas · Human Serome Atlas

CNDP1

Beta-Ala-His dipeptidase

Also known as: CN1, CNDP1_HUMAN, CPGL2, HsT2308, MGC10825

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KN2
Gene: CNDP1
Ensembl: ENSG00000150656
Chromosome: 18
Canonical length: 507 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

507 residues, UniProt reviewed canonical sequence.

>Q96KN2|CNDP1
     1  MDPKLGRMAA SLLAVLLLLL ERGMFSSPSP PPALLEKVFQ YIDLHQDEFV QTLKEWVAIE
    61  SDSVQPVPRF RQELFRMMAV AADTLQRLGA RVASVDMGPQ QLPDGQSLPI PPVILAELGS
   121  DPTKGTVCFY GHLDVQPADR GDGWLTDPYV LTEVDGKLYG RGATDNKGPV LAWINAVSAF
   181  RALEQDLPVN IKFIIEGMEE AGSVALEELV EKEKDRFFSG VDYIVISDNL WISQRKPAIT
   241  YGTRGNSYFM VEVKCRDQDF HSGTFGGILH EPMADLVALL GSLVDSSGHI LVPGIYDEVV
   301  PLTEEEINTY KAIHLDLEEY RNSSRVEKFL FDTKEEILMH LWRYPSLSIH GIEGAFDEPG
   361  TKTVIPGRVI GKFSIRLVPH MNVSAVEKQV TRHLEDVFSK RNSSNKMVVS MTLGLHPWIA
   421  NIDDTQYLAA KRAIRTVFGT EPDMIRDGST IPIAKMFQEI VHKSVVLIPL GAVDDGEHSQ
   481  NEKINRWNYI EGTKLFAAFF LEMAQLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNDP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 56 nTPM
midbrain: 37 nTPM
basal ganglia: 36 nTPM
hippocampal formation: 31 nTPM
cerebral cortex: 20 nTPM
hypothalamus: 18 nTPM

Single-cell type

oligodendrocytes: 739 nCPM
retinal pigment epithelial cells: 179 nCPM
hepatocytes: 62 nCPM
early spermatids: 23 nCPM
epididymal principal cells: 21 nCPM
endometrial luminal cells: 19 nCPM

Immune cell

basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 175 nTPM
cerebellum: 165 nTPM
white matter: 159 nTPM
midbrain: 156 nTPM
thalamus: 152 nTPM
pons: 150 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNDP1 as an antibody target. Whether an autoantibody or antibody against CNDP1 could matter depends on whether native CNDP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNDP1 is annotated as secreted, so native CNDP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CNDP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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