Seroatlas · Human Serome Atlas

CNDP2

Cytosolic non-specific dipeptidase

Also known as: CN2, CNDP2_HUMAN, CPGL, FLJ10830, HsT2298, PEPA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KP4
Gene: CNDP2
Ensembl: ENSG00000133313
Chromosome: 18
Canonical length: 475 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q96KP4|CNDP2
     1  MAALTTLFKY IDENQDRYIK KLAKWVAIQS VSAWPEKRGE IRRMMEVAAA DVKQLGGSVE
    61  LVDIGKQKLP DGSEIPLPPI LLGRLGSDPQ KKTVCIYGHL DVQPAALEDG WDSEPFTLVE
   121  RDGKLYGRGS TDDKGPVAGW INALEAYQKT GQEIPVNVRF CLEGMEESGS EGLDELIFAR
   181  KDTFFKDVDY VCISDNYWLG KKKPCITYGL RGICYFFIEV ECSNKDLHSG VYGGSVHEAM
   241  TDLILLMGSL VDKRGNILIP GINEAVAAVT EEEHKLYDDI DFDIEEFAKD VGAQILLHSH
   301  KKDILMHRWR YPSLSLHGIE GAFSGSGAKT VIPRKVVGKF SIRLVPNMTP EVVGEQVTSY
   361  LTKKFAELRS PNEFKVYMGH GGKPWVSDFS HPHYLAGRRA MKTVFGVEPD LTREGGSIPV
   421  TLTFQEATGK NVMLLPVGSA DDGAHSQNEK LNRYNYIEGT KMLAAYLYEV SQLKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNDP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 309 nTPM

Expression across tissuesHPA

Tissue

kidney: 309 nTPM
liver: 252 nTPM
small intestine: 240 nTPM
duodenum: 179 nTPM
spinal cord: 149 nTPM
thyroid gland: 149 nTPM

Single-cell type

enterocytes: 606 nCPM
endometrial luminal cells: 438 nCPM
breast lactating cells: 360 nCPM
endometrial glandular cells: 328 nCPM
hofbauer cells: 319 nCPM
migrating cytotrophoblasts: 241 nCPM

Immune cell

myeloid DC: 186 nTPM
non-classical monocyte: 175 nTPM
intermediate monocyte: 167 nTPM
plasmacytoid DC: 162 nTPM
total PBMC: 136 nTPM
NK-cell: 125 nTPM

Brain region

white matter: 172 nTPM
basal ganglia: 154 nTPM
thalamus: 154 nTPM
medulla oblongata: 150 nTPM
spinal cord: 144 nTPM
cerebellum: 140 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNDP2 as an antibody target. Whether an autoantibody or antibody against CNDP2 could matter depends on whether native CNDP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNDP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNDP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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