Seroatlas · Human Serome Atlas

MCTS1

Malignant T-cell-amplified sequence 1

Also known as: MCT-1, MCTS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULC4
Gene
MCTS1
Ensembl
ENSG00000232119
Chromosome
X
Canonical length
181 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Enables RNA cap binding activity; ribosomal small subunit binding activity; and translation factor activity, non-nucleic acid binding. Involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Is active in cytoplasm. Implicated in immunodeficiency 118. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

181 residues, UniProt reviewed canonical sequence.

>Q9ULC4|MCTS1
     1  MFKKFDEKEN VSNCIQLKTS VIKGIKNQLI EQFPGIEPWL NQIMPKKDPV KIVRCHEHIE
    61  ILTVNGELLF FRQREGPFYP TLRLLHKYPF ILPHQQVDKG AIKFVLSGAN IMCPGLTSPG
   121  AKLYPAAVDT IVAIMAEGKQ HALCVGVMKM SAEDIEKVNK GIGIENIHYL NDGLWHMKTY
   181  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCTS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 21 nTPM
  • liver: 19 nTPM
  • cerebral cortex: 19 nTPM
  • esophagus: 17 nTPM
  • hippocampal formation: 16 nTPM
  • kidney: 16 nTPM

Single-cell type

  • esophageal apical cells: 233 nCPM
  • extravillous trophoblasts: 192 nCPM
  • esophageal suprabasal cells: 153 nCPM
  • decidual stromal cells: 133 nCPM
  • hofbauer cells: 131 nCPM
  • late spermatids: 126 nCPM

Immune cell

  • plasmacytoid DC: 8.4 nTPM
  • myeloid DC: 6.5 nTPM
  • memory B-cell: 6.2 nTPM
  • T-reg: 6.1 nTPM
  • intermediate monocyte: 5.9 nTPM
  • non-classical monocyte: 5.9 nTPM

Brain region

  • hypothalamus: 8.1 nTPM
  • hippocampal formation: 8 nTPM
  • cerebral cortex: 7.4 nTPM
  • white matter: 7.3 nTPM
  • cerebellum: 7.2 nTPM
  • basal ganglia: 7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MCTS1.

Disease | AllUniProt

Conditions MCTS1 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 59 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Immunodeficiency 118

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.87
gnomAD missense Z
2.05
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MCTS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCTS1 as an antibody target. Whether an autoantibody or antibody against MCTS1 could matter depends on whether native MCTS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCTS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCTS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MCTS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...