Seroatlas · Human Serome Atlas

MCTS2

Malignant T-cell-amplified sequence 2

Also known as: MCTS2_HUMAN, MCTS2P, psiMCT-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A3B3IRV3
Gene
MCTS2
Ensembl
ENSG00000101898
Chromosome
20
Canonical length
181 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This locus represents a retrogene copy of MCTS1 (GeneID:28985) and contains an ORF similar to that parent gene. This locus is situated in a differentially methylated region (DMR) and transcripts in this region are imprinted. [provided by RefSeq, Nov 2021]

Canonical amino-acid sequenceUniProt

181 residues, UniProt reviewed canonical sequence.

>A0A3B3IRV3|MCTS2
     1  MFKKFDEKES VSNCIQLKTS VIKGIKSQLV EQFPGIEPWL NQIMPKKDPV KIVRCHEHTE
    61  ILTVSGELLF FRQRKGPFCP TLRLLHKYPF ILPHQQVDKG AIKFVLSGAN IMCPGLTSPG
   121  AKLYPAAVDT IVAVTAEGKQ HALCVGVMKM SAEDIEKVNK GIGIENIHYL NDGLWHMKTY
   181  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCTS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
2.5 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 2.5 nTPM
  • thymus: 2.4 nTPM
  • breast: 2.1 nTPM
  • ovary: 1.9 nTPM
  • urinary bladder: 1.8 nTPM
  • lymph node: 1.7 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • naive CD4 T-cell: 1.1 nTPM
  • myeloid DC: 1 nTPM
  • NK-cell: 1 nTPM
  • MAIT T-cell: 0.9 nTPM
  • naive B-cell: 0.9 nTPM
  • naive CD8 T-cell: 0.9 nTPM

Brain region

  • cerebellum: 6.3 nTPM
  • hypothalamus: 5.6 nTPM
  • basal ganglia: 5.2 nTPM
  • cerebral cortex: 5.2 nTPM
  • pons: 5.2 nTPM
  • white matter: 5 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCTS2 as an antibody target. Whether an autoantibody or antibody against MCTS2 could matter depends on whether native MCTS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCTS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCTS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MCTS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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