Seroatlas · Human Serome Atlas

EIF2D

Eukaryotic translation initiation factor 2D

Also known as: EIF2D_HUMAN, LGTN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P41214
Gene
EIF2D
Ensembl
ENSG00000143486
Chromosome
1
Canonical length
584 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

584 residues, UniProt reviewed canonical sequence.

>P41214|EIF2D
     1  MFAKAFRVKS NTAIKGSDRR KLRADVTTAF PTLGTDQVSE LVPGKEELNI VKLYAHKGDA
    61  VTVYVSGGNP ILFELEKNLY PTVYTLWSYP DLLPTFTTWP LVLEKLVGGA DLMLPGLVMP
   121  PAGLPQVQKG DLCAISLVGN RAPVAIGVAA MSTAEMLTSG LKGRGFSVLH TYQDHLWRSG
   181  NKSSPPSIAP LALDSADLSE EKGSVQMDST LQGDMRHMTL EGEEENGEVH QAREDKSLSE
   241  APEDTSTRGL NQDSTDSKTL QEQMDELLQQ CFLHALKCRV KKADLPLLTS TFLGSHMFSC
   301  CPEGRQLDIK KSSYKKLSKF LQQMQQEQII QVKELSKGVE SIVAVDWKHP RITSFVIPEP
   361  SPTSQTIQEG SREQPYHPPD IKPLYCVPAS MTLLFQESGH KKGSFLEGSE VRTIVINYAK
   421  KNDLVDADNK NLVRLDPILC DCILEKNEQH TVMKLPWDSL LTRCLEKLQP AYQVTLPGQE
   481  PIVKKGRICP IDITLAQRAS NKKVTVVRNL EAYGLDPYSV AAILQQRCQA STTVNPAPGA
   541  KDSLQVQIQG NQVHHLGWLL LEEYQLPRKH IQGLEKALKP GKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF2D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 60 nTPM
  • skeletal muscle: 51 nTPM
  • tongue: 48 nTPM
  • salivary gland: 44 nTPM
  • parathyroid gland: 41 nTPM
  • breast: 41 nTPM

Single-cell type

  • late primary spermatocytes: 69 nCPM
  • esophageal basal cells: 66 nCPM
  • late spermatids: 60 nCPM
  • esophageal suprabasal cells: 58 nCPM
  • decidual stromal cells: 53 nCPM
  • cytotrophoblasts: 51 nCPM

Immune cell

  • naive CD4 T-cell: 34 nTPM
  • memory B-cell: 33 nTPM
  • NK-cell: 30 nTPM
  • myeloid DC: 29 nTPM
  • naive B-cell: 27 nTPM
  • memory CD4 T-cell: 26 nTPM

Brain region

  • choroid plexus: 23 nTPM
  • white matter: 23 nTPM
  • basal ganglia: 20 nTPM
  • medulla oblongata: 19 nTPM
  • thalamus: 19 nTPM
  • midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
gnomAD missense Z
1.54
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF2D as an antibody target. Whether an autoantibody or antibody against EIF2D could matter depends on whether native EIF2D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF2D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF2D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF2D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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