Actinin-type actin-binding domain, conserved site
IPR001589
Definition
Alpha-actinin is a F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures PMID:3243032. The actin-binding domain of alpha-actinin seems to reside in the first 250 residues of the protein. A similar actin-binding domain has been found in the N-terminal region of many different actin-binding proteins [[cite:PMID:2058002], [cite:PMID:1892474]], like the beta chain of spectrin (or fodrin), dystrophin, the slime mold gelation factor (or ABP-120), filamin and fimbrin. This entry represents two conserved sites for the actin-binding domain.
23 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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