Seroatlas · Human Serome Atlas

PLS1

Plastin-1

Also known as: PLSI_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14651
Gene
PLS1
Ensembl
ENSG00000120756
Chromosome
3
Canonical length
629 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

629 residues, UniProt reviewed canonical sequence.

>Q14651|PLS1
     1  MENSTTTISR EELEELQEAF NKIDIDNSGY VSDYELQDLF KEASLPLPGY KVREIVEKIL
    61  SVADSNKDGK ISFEEFVSLM QELKSKDISK TFRKIINKRE GITAIGGTST ISSEGTQHSY
   121  SEEEKVAFVN WINKALENDP DCKHLIPMNP NDDSLFKSLA DGILLCKMIN LSEPDTIDER
   181  AINKKKLTPF TISENLNLAL NSASAIGCTV VNIGASDLKE GKPHLVLGLL WQIIKVGLFA
   241  DIEISRNEAL IALLNEGEEL EELMKLSPEE LLLRWVNYHL TNAGWHTISN FSQDIKDSRA
   301  YFHLLNQIAP KGGEDGPAIA IDLSGINETN DLKRAGLMLQ EADKLGCKQF VTPADVVSGN
   361  PKLNLAFVAN LFNTYPCLHK PNNNDIDMNL LEGESKEERT FRNWMNSLGV NPYINHLYSD
   421  LADALVIFQL YEMIRVPVNW SHVNKPPYPA LGGNMKKIEN CNYAVELGKN KAKFSLVGIA
   481  GQDLNEGNST LTLALVWQLM RRYTLNVLSD LGEGEKVNDE IIIKWVNQTL KSANKKTSIS
   541  SFKDKSISTS LPVLDLIDAI APNAVRQEMI RRENLSDEDK LNNAKYAISV ARKIGARIYA
   601  LPDDLVEVKP KMVMTVFACL MGKGLNRIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
297 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 297 nTPM
  • duodenum: 180 nTPM
  • colon: 135 nTPM
  • rectum: 130 nTPM
  • stomach: 43 nTPM
  • gallbladder: 26 nTPM

Single-cell type

  • enterocytes: 613 nCPM
  • colonocytes: 477 nCPM
  • goblet cells: 292 nCPM
  • foveolar cells: 261 nCPM
  • cone photoreceptor cells: 166 nCPM
  • tuft cells: 161 nCPM

Immune cell

  • NK-cell: 3 nTPM
  • eosinophil: 2.6 nTPM
  • naive CD8 T-cell: 2.5 nTPM
  • naive CD4 T-cell: 2.2 nTPM
  • memory CD8 T-cell: 2 nTPM
  • MAIT T-cell: 1.9 nTPM

Brain region

  • choroid plexus: 38 nTPM
  • pons: 19 nTPM
  • cerebellum: 16 nTPM
  • cerebral cortex: 16 nTPM
  • medulla oblongata: 15 nTPM
  • basal ganglia: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLS1.

Disease | AllUniProt

Conditions PLS1 is implicated in, by any mechanism.

  • Deafness, autosomal dominant, 76 (DFNA76) MIM:618787

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 162 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0
gnomAD missense Z
1.48
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLS1 as an antibody target. Whether an autoantibody or antibody against PLS1 could matter depends on whether native PLS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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