Seroatlas · Human Serome Atlas

LCP1

Plastin-2

Also known as: CP64, L-PLASTIN, LC64P, PLS2, PLSL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P13796
Gene
LCP1
Ensembl
ENSG00000136167
Chromosome
13
Canonical length
627 aa
Protein class
Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Actin filaments,Cytosol

OverviewNCBI Gene

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

627 residues, UniProt reviewed canonical sequence.

>P13796|LCP1
     1  MARGSVSDEE MMELREAFAK VDTDGNGYIS FNELNDLFKA ACLPLPGYRV REITENLMAT
    61  GDLDQDGRIS FDEFIKIFHG LKSTDVAKTF RKAINKKEGI CAIGGTSEQS SVGTQHSYSE
   121  EEKYAFVNWI NKALENDPDC RHVIPMNPNT NDLFNAVGDG IVLCKMINLS VPDTIDERTI
   181  NKKKLTPFTI QENLNLALNS ASAIGCHVVN IGAEDLKEGK PYLVLGLLWQ VIKIGLFADI
   241  ELSRNEALIA LLREGESLED LMKLSPEELL LRWANYHLEN AGCNKIGNFS TDIKDSKAYY
   301  HLLEQVAPKG DEEGVPAVVI DMSGLREKDD IQRAECMLQQ AERLGCRQFV TATDVVRGNP
   361  KLNLAFIANL FNRYPALHKP ENQDIDWGAL EGETREERTF RNWMNSLGVN PRVNHLYSDL
   421  SDALVIFQLY EKIKVPVDWN RVNKPPYPKL GGNMKKLENC NYAVELGKNQ AKFSLVGIGG
   481  QDLNEGNRTL TLALIWQLMR RYTLNILEEI GGGQKVNDDI IVNWVNETLR EAKKSSSISS
   541  FKDPKISTSL PVLDLIDAIQ PGSINYDLLK TENLNDDEKL NNAKYAISMA RKIGARVYAL
   601  PEDLVEVNPK MVMTVFACLM GKGMKRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
670 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 670 nTPM
  • tonsil: 567 nTPM
  • lymph node: 526 nTPM
  • thymus: 466 nTPM
  • epididymis: 380 nTPM
  • appendix: 375 nTPM

Single-cell type

  • neutrophils: 6,753 nCPM
  • neutrophil progenitors: 1,996 nCPM
  • monocyte progenitors: 1,309 nCPM
  • monocytes: 1,175 nCPM
  • epididymal principal cells: 754 nCPM
  • cdc: 638 nCPM

Immune cell

  • total PBMC: 3,641 nTPM
  • neutrophil: 1,916 nTPM
  • non-classical monocyte: 1,836 nTPM
  • intermediate monocyte: 1,807 nTPM
  • classical monocyte: 1,560 nTPM
  • myeloid DC: 1,135 nTPM

Brain region

  • cerebral cortex: 54 nTPM
  • white matter: 51 nTPM
  • thalamus: 41 nTPM
  • medulla oblongata: 32 nTPM
  • pons: 31 nTPM
  • midbrain: 28 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LCP1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 77 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.55
gnomAD missense Z
1.72
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LCP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCP1 as an antibody target. Whether an autoantibody or antibody against LCP1 could matter depends on whether native LCP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCP1 is annotated at the cell surface, where native LCP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LCP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LCP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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