CLMN

Protein identityUniProt · HPA

UniProt accession

Q96JQ2

Gene

CLMN

Ensembl

ENSG00000165959

Chromosome

14

Canonical length

1002 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to enable actin filament binding activity. Predicted to be involved in negative regulation of cell population proliferation. Predicted to act upstream of or within neuron projection development. Predicted to be located in membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in cytoplasm and nuclear outer membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1002 residues, UniProt reviewed canonical sequence.

>Q96JQ2|CLMN
     1  MAAHEWDWFQ REELIGQISD IRVQNLQVER ENVQKRTFTR WINLHLEKCN PPLEVKDLFV
    61  DIQDGKILMA LLEVLSGRNL LHEYKSSSHR IFRLNNIAKA LKFLEDSNVK LVSIDAAEIA
   121  DGNPSLVLGL IWNIILFFQI KELTGNLSRN SPSSSLSPGS GGTDSDSSFP PTPTAERSVA
   181  ISVKDQRKAI KALLAWVQRK TRKYGVAVQD FAGSWRSGLA FLAVIKAIDP SLVDMKQALE
   241  NSTRENLEKA FSIAQDALHI PRLLEPEDIM VDTPDEQSIM TYVAQFLERF PELEAEDIFD
   301  SDKEVPIEST FVRIKETPSE QESKVFVLTE NGERTYTVNH ETSHPPPSKV FVCDKPESMK
   361  EFRLDGVSSH ALSDSSTEFM HQIIDQVLQG GPGKTSDISE PSPESSILSS RKENGRSNSL
   421  PIKKTVHFEA DTYKDPFCSK NLSLCFEGSP RVAKESLRQD GHVLAVEVAE EKEQKQESSK
   481  IPESSSDKVA GDIFLVEGTN NNSQSSSCNG ALESTARHDE ESHSLSPPGE NTVMADSFQI
   541  KVNLMTVEAL EEGDYFEAIP LKASKFNSDL IDFASTSQAF NKVPSPHETK PDEDAEAFEN
   601  HAEKLGKRSI KSAHKKKDSP EPQVKMDKHE PHQDSGEEAE GCPSAPEETP VDKKPEVHEK
   661  AKRKSTRPHY EEEGEDDDLQ GVGEELSSSP PSSCVSLETL GSHSEEGLDF KPSPPLSKVS
   721  VIPHDLFYFP HYEVPLAAVL EAYVEDPEDL KNEEMDLEEP EGYMPDLDSR EEEADGSQSS
   781  SSSSVPGESL PSASDQVLYL SRGGVGTTPA SEPAPLAPHE DHQQRETKEN DPMDSHQSQE
   841  SPNLENIANP LEENVTKESI SSKKKEKRKH VDHVESSLFV APGSVQSSDD LEEDSSDYSI
   901  PSRTSHSDSS IYLRRHTHRS SESDHFSYVQ LRNAADLDDR RNRILTRKAN SSGEAMSLGS
   961  HSPQSDSLTQ LVQQPDMMYF ILFLWLLVYC LLLFPQLDVS RL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLMN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

31 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.7

gnomAD pLI

0

gnomAD missense Z

0.18

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of cell population proliferation
• neuron projection development
• nuclear migration

Molecular functions

• actin filament binding

Cellular components

• cytoplasm
• meiotic nuclear membrane microtubule tethering complex
• nuclear outer membrane

Protein domainsUniProt · Pfam · InterPro

• Actinin-type actin-binding domain, conserved site
• Calponin homology domain
• CH domain superfamily
• LINC complex-associated protein
• Calponin homology (CH) domain
• Calmin, second calponin homology domain
• Calmin, first calponin homology domain

KeywordsUniProt

• Actin-binding
• Membrane
• Phosphoprotein
• Repeat
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of CLMN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CTNNB1