Seroatlas · Human Serome Atlas

ACVR1C

Activin receptor type-1C

Also known as: ACV1C_HUMAN, ACVRLK7, ALK7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NER5
Gene
ACVR1C
Ensembl
ENSG00000123612
Chromosome
2
Canonical length
493 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>Q8NER5|ACVR1C
     1  MTRALCSALR QALLLLAAAA ELSPGLKCVC LLCDSSNFTC QTEGACWASV MLTNGKEQVI
    61  KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP TASPNAPKLG PMELAIIITV
   121  PVCLLSIAAM LTVWACQGRQ CSYRKKKRPN VEEPLSECNL VNAGKTLKDL IYDVTASGSG
   181  SGLPLLVQRT IARTIVLQEI VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ
   241  TVMLRHENIL GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMIKLALSIA
   301  SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCETCAIA DLGLAVKHDS ILNTIDIPQN
   361  PKVGTKRYMA PEMLDDTMNV NIFESFKRAD IYSVGLVYWE IARRCSVGGI VEEYQLPYYD
   421  MVPSDPSIEE MRKVVCDQKF RPSIPNQWQS CEALRVMGRI MRECWYANGA ARLTALRIKK
   481  TISQLCVKED CKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACVR1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 29 nTPM
  • breast: 6.1 nTPM
  • basal ganglia: 3.9 nTPM
  • colon: 3.9 nTPM
  • duodenum: 3.8 nTPM
  • small intestine: 3.2 nTPM

Single-cell type

  • adipocytes: 362 nCPM
  • adrenal medulla cells: 138 nCPM
  • bergmann glia: 116 nCPM
  • leydig cells: 82 nCPM
  • somatotrophs: 64 nCPM
  • oligodendrocytes: 43 nCPM

Immune cell

  • naive CD4 T-cell: 0.6 nTPM
  • memory CD4 T-cell: 0.4 nTPM
  • MAIT T-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • gdT-cell: 0.1 nTPM

Brain region

  • hypothalamus: 25 nTPM
  • hippocampal formation: 17 nTPM
  • basal ganglia: 17 nTPM
  • white matter: 11 nTPM
  • cerebral cortex: 11 nTPM
  • amygdala: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0
gnomAD missense Z
1.5
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACVR1C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACVR1C as an antibody target. Whether an autoantibody or antibody against ACVR1C could matter depends on whether native ACVR1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACVR1C is annotated at the cell surface, where native ACVR1C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ACVR1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACVR1C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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