BRINP1

Protein identityUniProt · HPA

UniProt accession

O60477

Gene

BRINP1

Ensembl

ENSG00000078725

Chromosome

9

Canonical length

761 aa

Protein class

Predicted intracellular proteins, Transporters

Subcellular location

Microtubules

Secretome location

Intracellular and membrane

OverviewNCBI Gene

This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

761 residues, UniProt reviewed canonical sequence.

>O60477|BRINP1
     1  MNWRFVELLY FLFIWGRISV QPSHQEPAGT DQHVSKEFDW LISDRGPFHH SRSYLSFVER
    61  HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE FQRSIRLLGR RPTTQQFIDT
   121  IIKKYGTHLL ISATLGGEEA LTMYMDKSRL DRKSGNATQS VEALHQLASS YFVDRDGTMR
   181  RLHEIQISTG AIKVTETRTG PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE
   241  KFVQSALSYI MCNGEGEYLC QNSQCRCQCA EEFPQCNCPI TDIQIMEYTL ANMAKSWAEA
   301  YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQN RYKLLQSATE AQRQKIQRTA
   361  RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN GFWGTFLESQ RSCVCHGSTT
   421  LCQRPIPCVI GGNNSCAMCS LANISLCGSC NKGYKLYRGR CEPQNVDSER SEQFISFETD
   481  LDFQDLELKY LLQKMDSRLY VHTTFISNEI RLDTFFDPRW RKRMSLTLKS NKNRMDFIHM
   541  VIGMSMRICQ MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW
   601  TLLLGNRWKT FFETVHIYLR SRTRLPTLLR NETGQGPVDL SDPSKRQFYI KISDVQVFGY
   661  SLRFNADLLR SAVQQVNQSY TQGGQFYSSS SVMLLLLDIR DRINRLAPPV APGKPQLDLF
   721  SCMLKHRLKL TNSEIIRVNH ALDLYNTEIL KQSDQMTAKL C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRINP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

38 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.28

gnomAD pLI

0.99

gnomAD missense Z

1.42

DepMap mean gene effect

0.12

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• behavioral fear response
• brain development
• cell population proliferation
• cellular response to retinoic acid
• central nervous system neuron development
• central nervous system neuron differentiation
• exploration behavior
• gene expression
• homeostasis of number of cells within a tissue
• maternal behavior
• negative regulation of mitotic cell cycle
• negative regulation of neurogenesis
• positive regulation of neuron differentiation
• proteasomal protein catabolic process
• protein stabilization
• short-term memory
• social behavior
• vocalization behavior

Cellular components

• cytoplasm
• dendrite
• glutamatergic synapse
• neuronal cell body

Protein domainsUniProt · Pfam · InterPro

• Membrane attack complex component/perforin (MACPF) domain
• BMP/retinoic acid-inducible neural-specific protein
• BRINP, EGF domain
• BRINP, C-terminal domain
• MAC/Perforin domain
• BRINP C-terminal domain
• BRNP1-3, EGF domain

KeywordsUniProt

• Cell cycle
• Cytoplasm
• Glycoprotein
• Growth arrest
• Neurogenesis
• Signal

InteractionsUniProt · HPA

Protein binding partners of BRINP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ZNF326