ZNF70
Zinc finger protein 70
Also known as: Cos17, MGC48959, ZNF70_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UC06
- Gene
- ZNF70
- Ensembl
- ENSG00000187792
- Chromosome
- 22
- Canonical length
- 446 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Cytosol
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytoplasm and megasporocyte nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
446 residues, UniProt reviewed canonical sequence.
>Q9UC06|ZNF70
1 MEVPPATKFG ETFAFENRLE SQQGLFPGED LGDPFLQERG LEQMAVIYKE IPLGEQDEEN
61 DDYEGNFSLC SSPVQHQSIP PGTRPQDDEL FGQTFLQKSD LSMCQIIHSE EPSPCDCAET
121 DRGDSGPNAP HRTPQPAKPY ACRECGKAFS QSSHLLRHLV IHTGEKPYEC CECGKAFSQS
181 SHLLRHQIIH TGEKPYECRE CGKAFRQSSA LTQHQKIHTG KRPYECRECG KDFSRSSSLR
241 KHERIHTGER PYQCKECGKS FNQSSGLSQH RKIHTLKKPH ECDLCGKAFC HRSHLIRHQR
301 IHTGKKPYKC DECGKAFSQS SNLIEHRKTH TGEKPYKCQK CGKAFSQSSS LIEHQRIHTG
361 EKPYECCQCG KAFCHSSALI QHQRIHTGKK PYTCECGKAF RHRSALIEHY KTHTREKPYV
421 CNLCGKSFRG SSHLIRHQKI HSGEKLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF70 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 3 nTPM
Expression across tissuesHPA
Tissue
- ovary: 3 nTPM
- retina: 2.8 nTPM
- skeletal muscle: 2.4 nTPM
- epididymis: 2.2 nTPM
- blood vessel: 2.1 nTPM
- cervix: 2 nTPM
Single-cell type
- hepatic stellate cells: 26 nCPM
- retinal horizontal cells: 16 nCPM
- myosatellite cells: 16 nCPM
- thymic myoid cells: 15 nCPM
- cone photoreceptor cells: 12 nCPM
- megakaryocyte progenitors: 12 nCPM
Immune cell
- basophil: 1.7 nTPM
- neutrophil: 1 nTPM
- NK-cell: 0.5 nTPM
- naive B-cell: 0.4 nTPM
- plasmacytoid DC: 0.4 nTPM
- classical monocyte: 0.3 nTPM
Brain region
- cerebellum: 12 nTPM
- white matter: 11 nTPM
- choroid plexus: 11 nTPM
- medulla oblongata: 11 nTPM
- thalamus: 9.8 nTPM
- midbrain: 9.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.81
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.41
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF70 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF70 as an antibody target. Whether an autoantibody or antibody against ZNF70 could matter depends on whether native ZNF70 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF70 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF70 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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