CNN3

Protein identityUniProt · HPA

UniProt accession

Q15417

Gene

CNN3

Ensembl

ENSG00000117519

Chromosome

1

Canonical length

329 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Actin filaments,Cytosol

OverviewNCBI Gene

This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associated with the cytoskeleton but is not involved in contraction. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q15417|CNN3
     1  MTHFNKGPSY GLSAEVKNKI ASKYDHQAEE DLRNWIEEVT GMSIGPNFQL GLKDGIILCE
    61  LINKLQPGSV KKVNESSLNW PQLENIGNFI KAIQAYGMKP HDIFEANDLF ENGNMTQVQT
   121  TLVALAGLAK TKGFHTTIDI GVKYAEKQTR RFDEGKLKAG QSVIGLQMGT NKCASQAGMT
   181  AYGTRRHLYD PKMQTDKPFD QTTISLQMGT NKGASQAGML APGTRRDIYD QKLTLQPVDN
   241  STISLQMGTN KVASQKGMSV YGLGRQVYDP KYCAAPTEPV IHNGSQGTGT NGSEISDSDY
   301  QAEYPDEYHG EYQDDYPRDY QYSDQGIDY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

265 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for CNN3 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.49

gnomAD pLI

0.6

gnomAD missense Z

2.24

DepMap mean gene effect

0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin filament organization
• actomyosin structure organization
• epithelial cell differentiation

Molecular functions

• actin filament binding
• cadherin binding involved in cell-cell adhesion
• calmodulin binding

Cellular components

• actin cytoskeleton
• adherens junction
• cytosol
• focal adhesion

Protein domainsUniProt · Pfam · InterPro

• Calponin repeat
• Calponin homology domain
• Calponin/LIMCH1
• Smooth muscle protein/calponin
• CH domain superfamily
• Calponin-like
• Calponin homology (CH) domain
• Calponin family repeat

KeywordsUniProt

• Acetylation
• Actin-binding
• Calmodulin-binding
• Methylation
• Phosphoprotein
• Repeat

InteractionsUniProt · HPA

Protein binding partners of CNN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ZDHHC22