Seroatlas · Human Serome Atlas

ZMAT2

Zinc finger matrin-type protein 2

Also known as: FLJ31121, hSNU23, Snu23, ZMAT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NC0
Gene: ZMAT2
Ensembl: ENSG00000146007
Chromosome: 5
Canonical length: 199 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q96NC0|ZMAT2
     1  MASGSGTKNL DFRRKWDKDE YEKLAEKRLT EEREKKDGKP VQPVKRELLR HRDYKVDLES
    61  KLGKTIVITK TTPQSEMGGY YCNVCDCVVK DSINFLDHIN GKKHQRNLGM SMRVERSTLD
   121  QVKKRFEVNK KKMEEKQKDY DFEERMKELR EEEEKAKAYK KEKQKEKKRR AEEDLTFEED
   181  DEMAAVMGFS GFGSTKKSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMAT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 99 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 99 nTPM
cerebral cortex: 90 nTPM
skeletal muscle: 83 nTPM
choroid plexus: 80 nTPM
amygdala: 74 nTPM
tongue: 74 nTPM

Single-cell type

esophageal apical cells: 371 nCPM
syncytiotrophoblasts: 249 nCPM
esophageal suprabasal cells: 197 nCPM
neutrophils: 175 nCPM
extravillous trophoblasts: 158 nCPM
cytotrophoblasts: 154 nCPM

Immune cell

neutrophil: 97 nTPM
basophil: 64 nTPM
eosinophil: 60 nTPM
MAIT T-cell: 39 nTPM
classical monocyte: 37 nTPM
T-reg: 35 nTPM

Brain region

basal ganglia: 76 nTPM
cerebral cortex: 75 nTPM
midbrain: 63 nTPM
white matter: 61 nTPM
hippocampal formation: 61 nTPM
hypothalamus: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 0.98
gnomAD missense Z: 2.63
DepMap mean gene effect: -1.44
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

via spliceosome
mRNA splicing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Matrin/U1-C-like, C2H2-type zinc finger
Zinc finger, double-stranded RNA binding
Zinc finger C2H2 superfamily
Zinc-finger double-stranded RNA-binding
U4/U6.U5 small nuclear ribonucleoprotein component Snu23

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMAT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMAT2 as an antibody target. Whether an autoantibody or antibody against ZMAT2 could matter depends on whether native ZMAT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMAT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMAT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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