Seroatlas · Human Serome Atlas

WDR33

pre-mRNA 3' end processing protein WDR33

Also known as: FLJ11294, NET14, WDC146, WDR33_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0J8
Gene: WDR33
Ensembl: ENSG00000136709
Chromosome: 2
Canonical length: 1336 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1336 residues, UniProt reviewed canonical sequence.

>Q9C0J8|WDR33
     1  MATEIGSPPR FFHMPRFQHQ APRQLFYKRP DFAQQQAMQQ LTFDGKRMRK AVNRKTIDYN
    61  PSVIKYLENR IWQRDQRDMR AIQPDAGYYN DLVPPIGMLN NPMNAVTTKF VRTSTNKVKC
   121  PVFVVRWTPE GRRLVTGASS GEFTLWNGLT FNFETILQAH DSPVRAMTWS HNDMWMLTAD
   181  HGGYVKYWQS NMNNVKMFQA HKEAIREASF SPTDNKFATC SDDGTVRIWD FLRCHEERIL
   241  RGHGADVKCV DWHPTKGLVV SGSKDSQQPI KFWDPKTGQS LATLHAHKNT VMEVKLNLNG
   301  NWLLTASRDH LCKLFDIRNL KEELQVFRGH KKEATAVAWH PVHEGLFASG GSDGSLLFWH
   361  VGVEKEVGGM EMAHEGMIWS LAWHPLGHIL CSGSNDHTSK FWTRNRPGDK MRDRYNLNLL
   421  PGMSEDGVEY DDLEPNSLAV IPGMGIPEQL KLAMEQEQMG KDESNEIEMT IPGLDWGMEE
   481  VMQKDQKKVP QKKVPYAKPI PAQFQQAWMQ NKVPIPAPNE VLNDRKEDIK LEEKKKTQAE
   541  IEQEMATLQY TNPQLLEQLK IERLAQKQVE QIQPPPSSGT PLLGPQPFPG QGPMSQIPQG
   601  FQQPHPSQQM PMNMAQMGPP GPQGQFRPPG PQGQMGPQGP PLHQGGGGPQ GFMGPQGPQG
   661  PPQGLPRPQD MHGPQGMQRH PGPHGPLGPQ GPPGPQGSSG PQGHMGPQGP PGPQGHIGPQ
   721  GPPGPQGHLG PQGPPGTQGM QGPPGPRGMQ GPPHPHGIQG GPGSQGIQGP VSQGPLMGLN
   781  PRGMQGPPGP RENQGPAPQG MIMGHPPQEM RGPHPPGGLL GHGPQEMRGP QEIRGMQGPP
   841  PQGSMLGPPQ ELRGPPGSQS QQGPPQGSLG PPPQGGMQGP PGPQGQQNPA RGPHPSQGPI
   901  PFQQQKTPLL GDGPRAPFNQ EGQSTGPPPL IPGLGQQGAQ GRIPPLNPGQ GPGPNKGDSR
   961  GPPNHHMGPM SERRHEQSGG PEHGPERGPF RGGQDCRGPP DRRGPHPDFP DDFSRPDDFH
  1021  PDKRFGHRLR EFEGRGGPLP QEEKWRRGGP GPPFPPDHRE FSEGDGRGAA RGPPGAWEGR
  1081  RPGDERFPRD PEDPRFRGRR EESFRRGAPP RHEGRAPPRG RDGFPGPEDF GPEENFDASE
  1141  EAARGRDLRG RGRGTPRGGR KGLLPTPDEF PRFEGGRKPD SWDGNREPGP GHEHFRDTPR
  1201  PDHPPHDGHS PASRERSSSL QGMDMASLPP RKRPWHDGPG TSEHREMEAP GGPSEDRGGK
  1261  GRGGPGPAQR VPKSGRSSSL DGEHHDGYHR DEPFGGPPGS GTPSRGGRSG SNWGRGSNMN
  1321  SGPPRRGASR GGGRGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 37 nTPM
thymus: 29 nTPM
ovary: 27 nTPM
spleen: 26 nTPM
liver: 26 nTPM
skin: 25 nTPM

Single-cell type

myonuclei: 264 nCPM
neutrophil progenitors: 228 nCPM
choroid plexus epithelial cells: 217 nCPM
oocytes: 203 nCPM
cardiomyocytes: 195 nCPM
thymocytes: 186 nCPM

Immune cell

basophil: 36 nTPM
eosinophil: 35 nTPM
NK-cell: 35 nTPM
T-reg: 35 nTPM
memory B-cell: 31 nTPM
naive B-cell: 28 nTPM

Brain region

cerebellum: 79 nTPM
choroid plexus: 48 nTPM
white matter: 46 nTPM
cerebral cortex: 44 nTPM
hypothalamus: 41 nTPM
basal ganglia: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 3.9
DepMap mean gene effect: -1.79
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
Collagen triple helix repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
Collagen triple helix repeat (20 copies)
Pre-mRNA 3' end processing protein Pfs2-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR33 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR33 as an antibody target. Whether an autoantibody or antibody against WDR33 could matter depends on whether native WDR33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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