von Willebrand factor C/EGF & Fibrillin
IPR052080
Definition
The von Willebrand factor C and EGF domain-containing protein family includes regulatory elements in signaling pathways, structural components of the extracellular matrix, and regulators of growth factor bioavailability. Members of this family are involved in the beta-catenin signaling pathway and may play a role in the prevention of hepatocellular carcinoma. Fibrillin-1 and -2 are crucial for the structural integrity and regulatory functions of microfibrils in connective tissues, influencing tissue homeostasis, osteoblast maturation, and osteoclastogenesis. They also interact with growth factors and integrins, contributing to cell adhesion and microfibril assembly. Latent-transforming growth factor beta-binding proteins control TGF-beta activation, maintaining it in a latent state and regulating its activation. The family's diverse functions include structural support, regulation of cell differentiation, and interaction with hormones that influence glucose metabolism and appetite.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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