Seroatlas · Human Serome Atlas

DMWD

Dystrophia myotonica WD repeat-containing protein

Also known as: D19S593E, DMR-N9, DMWD_HUMAN, gene59

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q09019
Gene: DMWD
Ensembl: ENSG00000185800
Chromosome: 19
Canonical length: 674 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Actin filaments

OverviewNCBI Gene

Enables deubiquitinase activator activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

674 residues, UniProt reviewed canonical sequence.

>Q09019|DMWD
     1  MAAGGAEGGS GPGAAMGDCA EIKSQFRTRE GFYKLLPGDG AARRSGPASA QTPVPPQPPQ
    61  PPPGPASASG PGAAGPASSP PPAGPGPGPA LPAVRLSLVR LGEPDSAGAG EPPATPAGLG
   121  SGGDRVCFNL GRELYFYPGC CRRGSQRSID LNKPIDKRIY KGTQPTCHDF NQFTAATETI
   181  SLLVGFSAGQ VQYLDLIKKD TSKLFNEERL IDKTKVTYLK WLPESESLFL ASHASGHLYL
   241  YNVSHPCASA PPQYSLLKQG EGFSVYAAKS KAPRNPLAKW AVGEGPLNEF AFSPDGRHLA
   301  CVSQDGCLRV FHFDSMLLRG LMKSYFGGLL CVCWSPDGRY VVTGGEDDLV TVWSFTEGRV
   361  VARGHGHKSW VNAVAFDPYT TRAEEAATAA GADGERSGEE EEEEPEAAGT GSAGGAPLSP
   421  LPKAGSITYR FGSAGQDTQF CLWDLTEDVL YPHPPLARTR TLPGTPGTTP PAASSSRGGE
   481  PGPGPLPRSL SRSNSLPHPA GGGKAGGPGV AAEPGTPFSI GRFATLTLQE RRDRGAEKEH
   541  KRYHSLGNIS RGGSGGSGSG GEKPSGPVPR SRLDPAKVLG TALCPRIHEV PLLEPLVCKK
   601  IAQERLTVLL FLEDCIITAC QEGLICTWAR PGKAFTDEET EAQTGEGSWP RSPSKSVVEG
   661  ISSQPGNSPS GTVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DMWD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 43 nTPM
skeletal muscle: 42 nTPM
cerebral cortex: 41 nTPM
heart muscle: 40 nTPM
colon: 37 nTPM
endometrium: 37 nTPM

Single-cell type

late spermatids: 45 nCPM
platelets: 16 nCPM
retinal pigment epithelial cells: 13 nCPM
tuft cells: 12 nCPM
gastric progenitor cells: 10 nCPM
thymic myoid cells: 9.5 nCPM

Immune cell

NK-cell: 1.8 nTPM
gdT-cell: 1.4 nTPM
naive B-cell: 1.4 nTPM
memory CD4 T-cell: 1.2 nTPM
MAIT T-cell: 1.1 nTPM
memory CD8 T-cell: 1.1 nTPM

Brain region

hippocampal formation: 109 nTPM
amygdala: 104 nTPM
cerebral cortex: 102 nTPM
basal ganglia: 93 nTPM
midbrain: 91 nTPM
hypothalamus: 89 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.37
gnomAD missense Z: 2.41
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

deubiquitinase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DMWD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DMWD as an antibody target. Whether an autoantibody or antibody against DMWD could matter depends on whether native DMWD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DMWD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DMWD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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