Seroatlas · Human Serome Atlas

WDR20

WD repeat-containing protein 20

Also known as: Bun107, DMR, FLJ33659, MGC33177, WDR20_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBZ3
Gene: WDR20
Ensembl: ENSG00000140153
Chromosome: 14
Canonical length: 569 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

569 residues, UniProt reviewed canonical sequence.

>Q8TBZ3|WDR20
     1  MATEGGGKEM NEIKTQFTTR EGLYKLLPHS EYSRPNRVPF NSQGSNPVRV SFVNLNDQSG
    61  NGDRLCFNVG RELYFYIYKG VRKAADLSKP IDKRIYKGTQ PTCHDFNHLT ATAESVSLLV
   121  GFSAGQVQLI DPIKKETSKL FNEERLIDKS RVTCVKWVPG SESLFLVAHS SGNMYLYNVE
   181  HTCGTTAPHY QLLKQGESFA VHTCKSKSTR NPLLKWTVGE GALNEFAFSP DGKFLACVSQ
   241  DGFLRVFNFD SVELHGTMKS YFGGLLCVCW SPDGKYIVTG GEDDLVTVWS FVDCRVIARG
   301  HGHKSWVSVV AFDPYTTSVE EGDPMEFSGS DEDFQDLLHF GRDRANSTQS RLSKRNSTDS
   361  RPVSVTYRFG SVGQDTQLCL WDLTEDILFP HQPLSRARTH TNVMNATSPP AGSNGNSVTT
   421  PGNSVPPPLP RSNSLPHSAV SNAGSKSSVM DGAIASGVSK FATLSLHDRK ERHHEKDHKR
   481  NHSMGHISSK SSDKLNLVTK TKTDPAKTLG TPLCPRMEDV PLLEPLICKK IAHERLTVLI
   541  FLEDCIVTAC QEGFICTWGR PGKVVSFNP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

retina: 28 nTPM
testis: 23 nTPM
adrenal gland: 16 nTPM
skin: 15 nTPM
duodenum: 15 nTPM
spinal cord: 14 nTPM

Single-cell type

early spermatids: 371 nCPM
late spermatids: 368 nCPM
rod photoreceptor cells: 248 nCPM
oligodendrocytes: 242 nCPM
sertoli cells: 188 nCPM
adrenal cortex cells: 176 nCPM

Immune cell

neutrophil: 40 nTPM
eosinophil: 38 nTPM
T-reg: 34 nTPM
NK-cell: 30 nTPM
naive CD4 T-cell: 29 nTPM
basophil: 29 nTPM

Brain region

white matter: 65 nTPM
cerebellum: 46 nTPM
cerebral cortex: 43 nTPM
medulla oblongata: 43 nTPM
basal ganglia: 41 nTPM
pons: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.92
gnomAD missense Z: 1.85
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

deubiquitinase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR20 as an antibody target. Whether an autoantibody or antibody against WDR20 could matter depends on whether native WDR20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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