Seroatlas · Human Serome Atlas

UQCC5

Ubiquinol-cytochrome c reductase complex assembly factor 5

Also known as: C3orf78, SMIM4, UQCC5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVI0
Gene: UQCC5
Ensembl: ENSG00000168273
Chromosome: 3
Canonical length: 70 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables mitochondrial ribosome binding activity. Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Is active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

70 residues, UniProt reviewed canonical sequence.

>Q8WVI0|UQCC5
     1  MFTRAQVRRI LQRVPGKQRF GIYRFLPFFF VLGGTMEWIM IKVRVGQETF YDVYRRKASE
    61  RQYQRRLEDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UQCC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 122 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 122 nTPM
adrenal gland: 117 nTPM
heart muscle: 95 nTPM
pituitary gland: 55 nTPM
tongue: 47 nTPM
thyroid gland: 46 nTPM

Single-cell type

parietal cells: 311 nCPM
prostatic club cells: 242 nCPM
hofbauer cells: 185 nCPM
hepatocytes: 181 nCPM
epicardial cells: 177 nCPM
epididymal basal cells: 161 nCPM

Immune cell

myeloid DC: 50 nTPM
classical monocyte: 44 nTPM
intermediate monocyte: 36 nTPM
T-reg: 30 nTPM
naive CD4 T-cell: 29 nTPM
memory CD4 T-cell: 28 nTPM

Brain region

cerebellum: 30 nTPM
choroid plexus: 27 nTPM
midbrain: 22 nTPM
white matter: 21 nTPM
medulla oblongata: 20 nTPM
pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0.2
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

mitochondrial ribosome binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ubiquinol-cytochrome-c reductase complex assembly factor 5
Uncharacterised protein family UPF0640

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UQCC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UQCC5 as an antibody target. Whether an autoantibody or antibody against UQCC5 could matter depends on whether native UQCC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UQCC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UQCC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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