Seroatlas · Human Serome Atlas

UNG

Uracil-DNA glycosylase

Also known as: DGU, HIGM4, UDG, UNG_HUMAN, UNG1, UNG2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P13051
Gene
UNG
Ensembl
ENSG00000076248
Chromosome
12
Canonical length
313 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>P13051|UNG
     1  MIGQKTLYSF FSPSPARKRH APSPEPAVQG TGVAGVPEES GDAAAIPAKK APAGQEEPGT
    61  PPSSPLSAEQ LDRIQRNKAA ALLRLAARNV PVGFGESWKK HLSGEFGKPY FIKLMGFVAE
   121  ERKHYTVYPP PHQVFTWTQM CDIKDVKVVI LGQDPYHGPN QAHGLCFSVQ RPVPPPPSLE
   181  NIYKELSTDI EDFVHPGHGD LSGWAKQGVL LLNAVLTVRA HQANSHKERG WEQFTDAVVS
   241  WLNQNSNGLV FLLWGSYAQK KGSAIDRKRH HVLQTAHPSP LSVYRGFFGC RHFSKTNELL
   301  QKSGKKPIDW KEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UNG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 54 nTPM
  • skeletal muscle: 41 nTPM
  • parathyroid gland: 31 nTPM
  • skin: 31 nTPM
  • tongue: 31 nTPM
  • liver: 30 nTPM

Single-cell type

  • oocytes: 170 nCPM
  • differentiating spermatogonia: 108 nCPM
  • migrating cytotrophoblasts: 85 nCPM
  • parietal cells: 80 nCPM
  • cytotrophoblasts: 76 nCPM
  • enteric stem cells: 62 nCPM

Immune cell

  • MAIT T-cell: 29 nTPM
  • memory CD8 T-cell: 24 nTPM
  • T-reg: 24 nTPM
  • memory CD4 T-cell: 23 nTPM
  • gdT-cell: 20 nTPM
  • naive CD8 T-cell: 17 nTPM

Brain region

  • hypothalamus: 28 nTPM
  • pons: 28 nTPM
  • medulla oblongata: 27 nTPM
  • thalamus: 26 nTPM
  • amygdala: 24 nTPM
  • basal ganglia: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UNG.

Disease | AllUniProt

Conditions UNG is implicated in, by any mechanism.

  • Immunodeficiency with hyper-IgM 5 (HIGM5) MIM:608106

Disease | GeneticClinVar

23 pathogenic / likely-pathogenic of 316 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
0.06
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UNG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UNG as an antibody target. Whether an autoantibody or antibody against UNG could matter depends on whether native UNG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UNG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UNG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UNG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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