Seroatlas · Human Serome Atlas

FAM72A

Protein FAM72A

Also known as: FA72A_HUMAN, LMPIP, MGC57827, p17, RP11-312O7.1, UGENE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TYM5
Gene: FAM72A
Ensembl: ENSG00000196550
Chromosome: 1
Canonical length: 149 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to act upstream of or within positive regulation of apoptotic process. Located in cytosol and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>Q5TYM5|FAM72A
     1  MSTNICSFKD RCVSILCCKF CKQVLSSRGM KAVLLADTEI DLFSTDIPPT NAVDFTGRCY
    61  FTKICKCKLK DIACLKCGNI VGYHVIVPCS SCLLSCNNGH FWMFHSQAVY DINRLDSTGV
   121  NVLLWGNLPE IEESTDEDVL NISAEECIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM72A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

lymph node: 10 nTPM
bone marrow: 8.1 nTPM
thymus: 8 nTPM
tonsil: 7 nTPM
testis: 6.8 nTPM
spleen: 6.1 nTPM

Single-cell type

late primary spermatocytes: 50 nCPM
epicardial cells: 41 nCPM
early spermatids: 12 nCPM
kupffer cells: 12 nCPM
late spermatids: 12 nCPM
early primary spermatocytes: 8.5 nCPM

Immune cell

intermediate monocyte: 8.7 nTPM
classical monocyte: 6.4 nTPM
non-classical monocyte: 5.4 nTPM
myeloid DC: 4.9 nTPM
T-reg: 3.2 nTPM
total PBMC: 2.3 nTPM

Brain region

cerebellum: 21 nTPM
pons: 14 nTPM
medulla oblongata: 13 nTPM
thalamus: 12 nTPM
white matter: 11 nTPM
midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0.03
gnomAD missense Z: 0.82

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM72A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM72A as an antibody target. Whether an autoantibody or antibody against FAM72A could matter depends on whether native FAM72A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM72A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM72A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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