Seroatlas · Human Serome Atlas

UBXN4

UBX domain-containing protein 4

Also known as: KIAA0242, UBXD2, UBXDC1, UBXN4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92575
Gene
UBXN4
Ensembl
ENSG00000144224
Chromosome
2
Canonical length
508 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q92575|UBXN4
     1  MLWFQGAIPA AIATAKRSGA VFVVFVAGDD EQSTQMAASW EDDKVTEASS NSFVAIKIDT
    61  KSEACLQFSQ IYPVVCVPSS FFIGDSGIPL EVIAGSVSAD ELVTRIHKVR QMHLLKSETS
   121  VANGSQSESS VSTPSASFEP NNTCENSQSR NAELCEIPPT SDTKSDTATG GESAGHATSS
   181  QEPSGCSDQR PAEDLNIRVE RLTKKLEERR EEKRKEEEQR EIKKEIERRK TGKEMLDYKR
   241  KQEEELTKRM LEERNREKAE DRAARERIKQ QIALDRAERA ARFAKTKEEV EAAKAAALLA
   301  KQAEMEVKRE SYARERSTVA RIQFRLPDGS SFTNQFPSDA PLEEARQFAA QTVGNTYGNF
   361  SLATMFPRRE FTKEDYKKKL LDLELAPSAS VVLLPAGRPT ASIVHSSSGD IWTLLGTVLY
   421  PFLAIWRLIS NFLFSNPPPT QTSVRVTSSE PPNPASSSKS EKREPVRKRV LEKRGDDFKK
   481  EGKIYRLRTQ DDGEDENNTW NGNSTQQM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBXN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
88 nTPM

Expression across tissuesHPA

Tissue

  • liver: 88 nTPM
  • retina: 79 nTPM
  • parathyroid gland: 79 nTPM
  • thymus: 71 nTPM
  • thyroid gland: 71 nTPM
  • pancreas: 69 nTPM

Single-cell type

  • early spermatids: 1,093 nCPM
  • late primary spermatocytes: 569 nCPM
  • syncytiotrophoblasts: 533 nCPM
  • epididymal principal cells: 436 nCPM
  • early primary spermatocytes: 435 nCPM
  • neutrophils: 433 nCPM

Immune cell

  • neutrophil: 74 nTPM
  • basophil: 63 nTPM
  • eosinophil: 59 nTPM
  • plasmacytoid DC: 57 nTPM
  • non-classical monocyte: 53 nTPM
  • T-reg: 52 nTPM

Brain region

  • white matter: 91 nTPM
  • choroid plexus: 89 nTPM
  • medulla oblongata: 81 nTPM
  • basal ganglia: 73 nTPM
  • cerebellum: 73 nTPM
  • midbrain: 72 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.15
gnomAD missense Z
1.46
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBXN4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBXN4 as an antibody target. Whether an autoantibody or antibody against UBXN4 could matter depends on whether native UBXN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBXN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBXN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBXN4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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