Seroatlas · Human Serome Atlas

TXNDC11

Thioredoxin domain-containing protein 11

Also known as: EFP1, TXD11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PKC3
Gene: TXNDC11
Ensembl: ENSG00000153066
Chromosome: 16
Canonical length: 985 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

985 residues, UniProt reviewed canonical sequence.

>Q6PKC3|TXNDC11
     1  MSECGGRGGG SSSSEDAEDE GGGGGGPAGS DCLSSSPTLA TASSAGRLRR GLRGAFLMAR
    61  QRPELLCGAV ALGCALLLAL KFTCSRAKDV IIPAKPPVSF FSLRSPVLDL FQGQLDYAEY
   121  VRRDSEVVLL FFYAPWCGQS IAARAEIEQA ASRLSDQVLF VAINCWWNQG KCRKQKHFFY
   181  FPVIYLYHRS FGPIEYKGPM SAVYIEKFVR RVMKPLLYIP SQSELLDFLS NYEPGVLGYF
   241  EFSGSPQPPG YLTFFTSALH SLKKALESTS SPRALVSFTG EWHLETKIYV LDYLGTVRFG
   301  VITNKHLAKL VSLVHSGSVY LHRHFNTSLV FPREVLNYTA ENICKWALEN QETLFRWLRP
   361  HGGKSLLLNN ELKKGPALFL FIPFNPLAES HPLIDEITEV ALEYNNCHGD QVVERLLQHL
   421  RRVDAPVLES LALEVPAQLP DPPTITASPC CNTVVLPQWH SFSRTHNVCE LCVNQTSGGM
   481  KPSSVSVPQC SFFEMAAALD SFYLKEQTFY HVASDSIECS NFLTSYSPFS YYTACCRTIS
   541  RGVSGFIDSE QGVFEAPTVA FSSLEKKCEV DAPSSVPHIE ENRYLFPEVD MTSTNFTGLS
   601  CRTNKTLNIY LLDSNLFWLY AERLGAPSST QVKEFAAIVD VKEESHYILD PKQALMKLTL
   661  ESFIQNFSVL YSPLKRHLIG SGSAQFPSQH LITEVTTDTF WEVVLQKQDV LLLYYAPWCG
   721  FCPSLNHIFI QLARNLPMDT FTVARIDVSQ NDLPWEFMVD RLPTVLFFPC NRKDLSVKYP
   781  EDVPITLPNL LRFILHHSDP ASSPQNVANS PTKECLQSEA VLQRGHISHL EREIQKLRAE
   841  ISSLQRAQVQ VESQLSSARR DEHRLRQQQR ALEEQHSLLH AHSEQLQALY EQKTRELQEL
   901  ARKLQELADA SENLLTENTW LKILVATMER KLEGRDGAES LAAQREVHPK QPEPSATPQL
   961  PGSSPPPANV SATLVSERNK ENRTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TXNDC11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 52 nTPM
parathyroid gland: 42 nTPM
liver: 42 nTPM
duodenum: 36 nTPM
stomach: 34 nTPM
lung: 33 nTPM

Single-cell type

plasma cells: 588 nCPM
neutrophils: 309 nCPM
monocyte progenitors: 200 nCPM
neutrophil progenitors: 189 nCPM
monocytes: 187 nCPM
epididymal principal cells: 164 nCPM

Immune cell

eosinophil: 7.7 nTPM
T-reg: 6.8 nTPM
NK-cell: 5.6 nTPM
naive B-cell: 4.6 nTPM
MAIT T-cell: 4.5 nTPM
memory CD8 T-cell: 4.1 nTPM

Brain region

choroid plexus: 36 nTPM
cerebellum: 17 nTPM
basal ganglia: 13 nTPM
hippocampal formation: 12 nTPM
thalamus: 12 nTPM
white matter: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TXNDC11.

Disease | ImmuneIEDB

Conditions an epitope on TXNDC11 was assayed in.

colon adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: -1.28
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

Thioredoxin domain
Thioredoxin-like superfamily
Thioredoxin
Thioredoxin domain-containing protein 11
TXNDC11, thioredoxin-like domain
TXNDC11, thioredoxin-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TXNDC11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TXNDC11 as an antibody target. Whether an autoantibody or antibody against TXNDC11 could matter depends on whether native TXNDC11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TXNDC11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TXNDC11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...