Seroatlas · Human Serome Atlas

TRPM4

Transient receptor potential cation channel subfamily M member 4

Also known as: FLJ20041, TRPM4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TD43
Gene: TRPM4
Ensembl: ENSG00000130529
Chromosome: 19
Canonical length: 1214 aa
Protein class: Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Subcellular location: Nucleoplasm,Plasma membrane
Quaternary structure: Homotetramer

OverviewNCBI Gene

The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

1214 residues, UniProt reviewed canonical sequence.

>Q8TD43|TRPM4
     1  MVVPEKEQSW IPKIFKKKTC TTFIVDSTDP GGTLCQCGRP RTAHPAVAME DAFGAAVVTV
    61  WDSDAHTTEK PTDAYGELDF TGAGRKHSNF LRLSDRTDPA AVYSLVTRTW GFRAPNLVVS
   121  VLGGSGGPVL QTWLQDLLRR GLVRAAQSTG AWIVTGGLHT GIGRHVGVAV RDHQMASTGG
   181  TKVVAMGVAP WGVVRNRDTL INPKGSFPAR YRWRGDPEDG VQFPLDYNYS AFFLVDDGTH
   241  GCLGGENRFR LRLESYISQQ KTGVGGTGID IPVLLLLIDG DEKMLTRIEN ATQAQLPCLL
   301  VAGSGGAADC LAETLEDTLA PGSGGARQGE ARDRIRRFFP KGDLEVLQAQ VERIMTRKEL
   361  LTVYSSEDGS EEFETIVLKA LVKACGSSEA SAYLDELRLA VAWNRVDIAQ SELFRGDIQW
   421  RSFHLEASLM DALLNDRPEF VRLLISHGLS LGHFLTPMRL AQLYSAAPSN SLIRNLLDQA
   481  SHSAGTKAPA LKGGAAELRP PDVGHVLRML LGKMCAPRYP SGGAWDPHPG QGFGESMYLL
   541  SDKATSPLSL DAGLGQAPWS DLLLWALLLN RAQMAMYFWE MGSNAVSSAL GACLLLRVMA
   601  RLEPDAEEAA RRKDLAFKFE GMGVDLFGEC YRSSEVRAAR LLLRRCPLWG DATCLQLAMQ
   661  ADARAFFAQD GVQSLLTQKW WGDMASTTPI WALVLAFFCP PLIYTRLITF RKSEEEPTRE
   721  ELEFDMDSVI NGEGPVGTAD PAEKTPLGVP RQSGRPGCCG GRCGGRRCLR RWFHFWGAPV
   781  TIFMGNVVSY LLFLLLFSRV LLVDFQPAPP GSLELLLYFW AFTLLCEELR QGLSGGGGSL
   841  ASGGPGPGHA SLSQRLRLYL ADSWNQCDLV ALTCFLLGVG CRLTPGLYHL GRTVLCIDFM
   901  VFTVRLLHIF TVNKQLGPKI VIVSKMMKDV FFFLFFLGVW LVAYGVATEG LLRPRDSDFP
   961  SILRRVFYRP YLQIFGQIPQ EDMDVALMEH SNCSSEPGFW AHPPGAQAGT CVSQYANWLV
  1021  VLLLVIFLLV ANILLVNLLI AMFSYTFGKV QGNSDLYWKA QRYRLIREFH SRPALAPPFI
  1081  VISHLRLLLR QLCRRPRSPQ PSSPALEHFR VYLSKEAERK LLTWESVHKE NFLLARARDK
  1141  RESDSERLKR TSQKVDLALK QLGHIREYEQ RLKVLEREVQ QCSRVLGWVA EALSRSALLP
  1201  PGGPPPPDLP GSKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRPM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

colon: 46 nTPM
prostate: 36 nTPM
salivary gland: 27 nTPM
skin: 26 nTPM
duodenum: 24 nTPM
kidney: 24 nTPM

Single-cell type

colonocytes: 190 nCPM
goblet cells: 130 nCPM
cardiomyocytes: 119 nCPM
prostatic glandular cells: 94 nCPM
enteric transient amplifying cells: 92 nCPM
salivary duct cells: 89 nCPM

Immune cell

classical monocyte: 4.3 nTPM
myeloid DC: 3.3 nTPM
plasmacytoid DC: 3 nTPM
neutrophil: 2.8 nTPM
intermediate monocyte: 2.4 nTPM
basophil: 1.7 nTPM

Brain region

cerebellum: 24 nTPM
midbrain: 23 nTPM
thalamus: 22 nTPM
pons: 22 nTPM
medulla oblongata: 20 nTPM
cerebral cortex: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRPM4.

Disease | AllUniProt

Conditions TRPM4 is implicated in, by any mechanism.

Progressive familial heart block 1B (PFHB1B) MIM:604559
Erythrokeratodermia variabilis et progressiva 6 (EKVP6) MIM:618531

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 2,243 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Progressive familial heart block type IB
Erythrokeratodermia variabilis et progressiva 6
TRPM4-related disorder
Cardiovascular phenotype
Exertional Heat Illness

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 0.97
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRPM4 as an antibody target. Whether an autoantibody or antibody against TRPM4 could matter depends on whether native TRPM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRPM4 is annotated at the cell surface, where native TRPM4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRPM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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