TRPC3

Protein identityUniProt · HPA

UniProt accession

Q13507

Gene

TRPC3

Ensembl

ENSG00000138741

Chromosome

4

Canonical length

921 aa

Protein class

Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels

Quaternary structure

Homotetramer

OverviewNCBI Gene

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

921 residues, UniProt reviewed canonical sequence.

>Q13507|TRPC3
     1  MSTKVRKCKE QARVTFPAPE EEEDEGEDEG AEPQRRRRGW RGVNGGLEPR SAPSQREPHG
    61  YCPPPFSHGP DLSMEGSPSL RRMTVMREKG RRQAVRGPAF MFNDRGTSLT AEEERFLDAA
   121  EYGNIPVVRK MLEESKTLNV NCVDYMGQNA LQLAVGNEHL EVTELLLKKE NLARIGDALL
   181  LAISKGYVRI VEAILNHPGF AASKRLTLSP CEQELQDDDF YAYDEDGTRF SPDITPIILA
   241  AHCQKYEVVH MLLMKGARIE RPHDYFCKCG DCMEKQRHDS FSHSRSRINA YKGLASPAYL
   301  SLSSEDPVLT ALELSNELAK LANIEKEFKN DYRKLSMQCK DFVVGVLDLC RDSEEVEAIL
   361  NGDLESAEPL EVHRHKASLS RVKLAIKYEV KKFVAHPNCQ QQLLTIWYEN LSGLREQTIA
   421  IKCLVVLVVA LGLPFLAIGY WIAPCSRLGK ILRSPFMKFV AHAASFIIFL GLLVFNASDR
   481  FEGITTLPNI TVTDYPKQIF RVKTTQFTWT EMLIMVWVLG MMWSECKELW LEGPREYILQ
   541  LWNVLDFGML SIFIAAFTAR FLAFLQATKA QQYVDSYVQE SDLSEVTLPP EIQYFTYARD
   601  KWLPSDPQII SEGLYAIAVV LSFSRIAYIL PANESFGPLQ ISLGRTVKDI FKFMVLFIMV
   661  FFAFMIGMFI LYSYYLGAKV NAAFTTVEES FKTLFWSIFG LSEVTSVVLK YDHKFIENIG
   721  YVLYGIYNVT MVVVLLNMLI AMINSSYQEI EDDSDVEWKF ARSKLWLSYF DDGKTLPPPF
   781  SLVPSPKSFV YFIMRIVNFP KCRRRRLQKD IEMGMGNSKS RLNLFTQSNS RVFESHSFNS
   841  ILNQPTRYQQ IMKRLIKRYV LKAQVDKEND EVNEGELKEI KQDISSLRYE LLEDKSQATE
   901  ELAILIHKLS EKLNPSMLRC E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRPC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

7 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRPC3.

Disease | AllUniProt

Conditions TRPC3 is implicated in, by any mechanism.

• Spinocerebellar ataxia 41 (SCA41) MIM:616410

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 224 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Spinocerebellar ataxia type 41

ReferencesPubMed · IEDB

Publications for TRPC3 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.7

gnomAD pLI

0

gnomAD missense Z

3.84

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• calcium ion transmembrane transport
• calcium ion transport
• phototransduction
• positive regulation of calcium ion transport into cytosol
• positive regulation of cardiac muscle hypertrophy in response to stress
• regulation of cytosolic calcium ion concentration
• response to ATP
• response to calcium ion
• single fertilization

Molecular functions

• calcium channel activity
• calcium-activated cation channel activity
• inositol 1,4,5 trisphosphate binding
• metal ion binding
• store-operated calcium channel activity

Cellular components

• cation channel complex
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Ankyrin repeat
• Transient receptor potential channel, canonical
• Ion transport domain
• Transient receptor ion channel domain
• Ankyrin repeat-containing domain superfamily
• Ion transport protein
• Transient receptor ion channel II
• Ankyrin repeats (3 copies)
• Transient receptor potential channel, canonical 3

KeywordsUniProt

• ANK repeat
• Calcium
• Calcium channel
• Calcium transport
• Cell membrane
• Glycoprotein
• Ion channel
• Ion transport
• Membrane
• Metal-binding
• Neurodegeneration
• Repeat
• Spinocerebellar ataxia
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of TRPC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ITPR1
• ITPR3
• JPH2
• MX1
• RNF24