RNF24
RING finger protein 24
Also known as: G1L, RNF24_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y225
- Gene
- RNF24
- Ensembl
- ENSG00000101236
- Chromosome
- 20
- Canonical length
- 148 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Golgi apparatus
OverviewNCBI Gene
This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]
Canonical amino-acid sequenceUniProt
148 residues, UniProt reviewed canonical sequence.
>Q9Y225|RNF24
1 MSSDFPHYNF RMPNIGFQNL PLNIYIVVFG TAIFVFILSL LFCCYLIRLR HQAHKEFYAY
61 KQVILKEKVK ELNLHELCAV CLEDFKPRDE LGICPCKHAF HRKCLIKWLE VRKVCPLCNM
121 PVLQLAQLHS KQDRGPPQGP LPGAENIVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RNF24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 49 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 49 nTPM
- blood vessel: 17 nTPM
- epididymis: 14 nTPM
- lung: 12 nTPM
- cerebral cortex: 10 nTPM
- spleen: 8.7 nTPM
Single-cell type
- neutrophils: 2,569 nCPM
- neutrophil progenitors: 1,078 nCPM
- epicardial cells: 409 nCPM
- respiratory basal cells: 286 nCPM
- mesothelial cells: 279 nCPM
- platelets: 264 nCPM
Immune cell
- neutrophil: 239 nTPM
- basophil: 109 nTPM
- eosinophil: 51 nTPM
- classical monocyte: 24 nTPM
- myeloid DC: 19 nTPM
- non-classical monocyte: 13 nTPM
Brain region
- hippocampal formation: 34 nTPM
- cerebral cortex: 34 nTPM
- hypothalamus: 32 nTPM
- basal ganglia: 32 nTPM
- amygdala: 30 nTPM
- thalamus: 30 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.91
- gnomAD pLI
- 0.03
- gnomAD missense Z
- 1.12
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Zinc finger, RING-type
- Zinc finger, RING-CH-type
- Zinc finger, RING/FYVE/PHD-type
- HRD1 family E3 ubiquitin-protein ligases
- Ring finger domain
- RING finger protein 24, RING finger, H2 subclass
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RNF24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RNF24 as an antibody target. Whether an autoantibody or antibody against RNF24 could matter depends on whether native RNF24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RNF24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RNF24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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