Seroatlas · Human Serome Atlas

TRIAP1

TP53-regulated inhibitor of apoptosis 1

Also known as: HSPC132, MDM35, P53CSV, TRIA1_HUMAN, WF-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43715
Gene: TRIAP1
Ensembl: ENSG00000170855
Chromosome: 12
Canonical length: 76 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables p53 binding activity. Contributes to phosphatidic acid transfer activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of apoptotic signaling pathway; and positive regulation of phospholipid transport. Located in mitochondrial intermembrane space and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

76 residues, UniProt reviewed canonical sequence.

>O43715|TRIAP1
     1  MNSVGEACTD MKREYDQCFN RWFAEKFLKG DSSGDPCTDL FKRYQQCVQK AIKEKEIPIE
    61  GLEFMGHGKE KPENSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

liver: 62 nTPM
skeletal muscle: 57 nTPM
pancreas: 50 nTPM
tongue: 37 nTPM
bone marrow: 31 nTPM
rectum: 29 nTPM

Single-cell type

migrating cytotrophoblasts: 162 nCPM
cytotrophoblasts: 148 nCPM
esophageal suprabasal cells: 97 nCPM
extravillous trophoblasts: 92 nCPM
esophageal basal cells: 91 nCPM
oocytes: 83 nCPM

Immune cell

myeloid DC: 59 nTPM
plasmacytoid DC: 53 nTPM
intermediate monocyte: 53 nTPM
NK-cell: 50 nTPM
MAIT T-cell: 49 nTPM
naive CD4 T-cell: 48 nTPM

Brain region

choroid plexus: 10 nTPM
white matter: 10 nTPM
hypothalamus: 8.7 nTPM
spinal cord: 8.2 nTPM
cerebellum: 8 nTPM
cerebral cortex: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0.06
gnomAD missense Z: 0.23
DepMap mean gene effect: -1.2
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

p53 binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Mitochondrial distribution/morphology family 35/apoptosis
Uncharacterised protein family (UPF0203)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIAP1 as an antibody target. Whether an autoantibody or antibody against TRIAP1 could matter depends on whether native TRIAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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