Seroatlas · Human Serome Atlas

PRELID3A

PRELI domain containing protein 3A

Also known as: C18orf43, FLJ31484, HFL-EDDG1, PLD3A_HUMAN, SLMO1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96N28
Gene: PRELID3A
Ensembl: ENSG00000141391
Chromosome: 18
Canonical length: 172 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables phosphatidic acid transfer activity. Involved in phospholipid transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>Q96N28|PRELID3A
     1  MKIWSSEHVF GHPWDTVIQA AMRKYPNPMN PSVLGVDVLQ RRVDGRGRLH SLRLLSTEWG
    61  LPSLVRAILG TSRTLTYIRE HSVVDPVEKK MELCSTNITL TNLVSVNERL VYTPHPENPE
   121  MTVLTQEAII TVKGISLGSY LESLMANTIS SNAKKGWAAI EWIIEHSESA VS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRELID3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 16 nTPM
cerebellum: 15 nTPM
cerebral cortex: 14 nTPM
hypothalamus: 12 nTPM
midbrain: 12 nTPM
amygdala: 11 nTPM

Single-cell type

retinal ganglion cells: 31 nCPM
bergmann glia: 30 nCPM
retinal amacrine cells: 28 nCPM
retinal bipolar cells: 27 nCPM
other brain neurons: 23 nCPM
astrocytes: 22 nCPM

Immune cell

basophil: 3 nTPM
eosinophil: 1.6 nTPM
neutrophil: 1.2 nTPM
memory B-cell: 0.7 nTPM
classical monocyte: 0.5 nTPM
naive B-cell: 0.5 nTPM

Brain region

white matter: 59 nTPM
choroid plexus: 44 nTPM
medulla oblongata: 42 nTPM
pons: 42 nTPM
cerebral cortex: 38 nTPM
thalamus: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

phospholipid transport

Molecular functions

phosphatidic acid transfer activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRELID3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIAP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRELID3A as an antibody target. Whether an autoantibody or antibody against PRELID3A could matter depends on whether native PRELID3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRELID3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRELID3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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