Seroatlas · Human Serome Atlas

PRELID1

PRELI domain-containing protein 1, mitochondrial

Also known as: CGI-106, PRELI, PRLD1_HUMAN, PX19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y255
Gene: PRELID1
Ensembl: ENSG00000169230
Chromosome: 5
Canonical length: 219 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>Q9Y255|PRELID1
     1  MVKYFLGQSV LRSSWDQVFA AFWQRYPNPY SKHVLTEDIV HREVTPDQKL LSRRLLTKTN
    61  RMPRWAERLF PANVAHSVYV LEDSIVDPQN QTMTTFTWNI NHARLMVVEE RCVYCVNSDN
   121  SGWTEIRREA WVSSSLFGVS RAVQEFGLAR FKSNVTKTMK GFEYILAKLQ GEAPSKTLVE
   181  TAKEAKEKAK ETALAATEKA KDLASKAATK KQQQQQQFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRELID1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 263 nTPM

Expression across tissuesHPA

Tissue

pancreas: 263 nTPM
liver: 190 nTPM
esophagus: 151 nTPM
kidney: 145 nTPM
colon: 124 nTPM
small intestine: 123 nTPM

Single-cell type

esophageal apical cells: 1,032 nCPM
syncytiotrophoblasts: 1,029 nCPM
cytotrophoblasts: 890 nCPM
esophageal suprabasal cells: 731 nCPM
migrating cytotrophoblasts: 706 nCPM
enterocytes: 621 nCPM

Immune cell

eosinophil: 1,200 nTPM
non-classical monocyte: 994 nTPM
intermediate monocyte: 988 nTPM
myeloid DC: 775 nTPM
classical monocyte: 765 nTPM
total PBMC: 613 nTPM

Brain region

thalamus: 49 nTPM
spinal cord: 43 nTPM
pons: 42 nTPM
midbrain: 41 nTPM
hypothalamus: 40 nTPM
choroid plexus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.12
gnomAD missense Z: 1.26
DepMap mean gene effect: -2.5
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRELID1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRELID1 as an antibody target. Whether an autoantibody or antibody against PRELID1 could matter depends on whether native PRELID1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRELID1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRELID1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...