Seroatlas · Human Serome Atlas

PRELID3B

PRELI domain containing protein 3B

Also known as: C20orf45, dJ543J19.5, PLD3B_HUMAN, SLMO2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3B1
Gene: PRELID3B
Ensembl: ENSG00000101166
Chromosome: 20
Canonical length: 194 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable phosphatidic acid transfer activity. Predicted to be involved in phospholipid transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>Q9Y3B1|PRELID3B
     1  MKIWTSEHVF DHPWETVTTA AMQKYPNPMN PSVVGVDVLD RHIDPSGKLH SHRLLSTEWG
    61  LPSIVKSLIG AARTKTYVQE HSVVDPVEKT MELKSTNISF TNMVSVDERL IYKPHPQDPE
   121  KTVLTQEAII TVKGVSLSSY LEGLMASTIS SNASKGREAM EWVIHKLNAE IEELTASARG
   181  TIRTPMAAAA FAEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRELID3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 87 nTPM

Expression across tissuesHPA

Tissue

duodenum: 87 nTPM
small intestine: 79 nTPM
colon: 65 nTPM
rectum: 61 nTPM
urinary bladder: 46 nTPM
stomach: 42 nTPM

Single-cell type

esophageal apical cells: 618 nCPM
gastric progenitor cells: 177 nCPM
syncytiotrophoblasts: 146 nCPM
extravillous trophoblasts: 139 nCPM
esophageal suprabasal cells: 134 nCPM
enterocytes: 132 nCPM

Immune cell

basophil: 52 nTPM
T-reg: 47 nTPM
NK-cell: 46 nTPM
memory B-cell: 41 nTPM
MAIT T-cell: 41 nTPM
memory CD4 T-cell: 40 nTPM

Brain region

white matter: 28 nTPM
hypothalamus: 27 nTPM
medulla oblongata: 26 nTPM
cerebellum: 25 nTPM
midbrain: 25 nTPM
pons: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.14
DepMap mean gene effect: -1.67
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

phospholipid transport

Molecular functions

phosphatidic acid transfer activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of PRELID3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIAP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRELID3B as an antibody target. Whether an autoantibody or antibody against PRELID3B could matter depends on whether native PRELID3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRELID3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRELID3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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