Seroatlas · Human Serome Atlas

TRABD

TraB domain-containing protein

Also known as: PP2447, TRABD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4I3
Gene: TRABD
Ensembl: ENSG00000170638
Chromosome: 22
Canonical length: 376 aa
Protein class: Plasma proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables mitochondrion-mitochondrion outer membrane tether activity. Involved in mitochondrial fusion. Located in mitochondrion. Is active in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>Q9H4I3|TRABD
     1  MDGEEQQPPH EANVEPVVPS EASEPVPRVL SGDPQNLSDV DAFNLLLEMK LKRRRQRPNL
    61  PRTVTQLVAE DGSRVYVVGT AHFSDDSKRD VVKTIREVQP DVVVVELCQY RVSMLKMDES
   121  TLLREAQELS LEKLQQAVRQ NGLMSGLMQM LLLKVSAHIT EQLGMAPGGE FREAFKEASK
   181  VPFCKFHLGD RPIPVTFKRA IAALSFWQKV RLAWGLCFLS DPISKDDVER CKQKDLLEQM
   241  MAEMIGEFPD LHRTIVSERD VYLTYMLRQA ARRLELPRAS DAEPRKCVPS VVVGVVGMGH
   301  VPGIEKNWST DLNIQEIMTV PPPSVSGRVS RLAVKAAFFG LLGYSLYWMG RRTASLVLSL
   361  PAAQYCLQRV TEARHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRABD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

pancreas: 72 nTPM
bone marrow: 58 nTPM
esophagus: 40 nTPM
liver: 40 nTPM
spleen: 37 nTPM
lymph node: 31 nTPM

Single-cell type

esophageal apical cells: 198 nCPM
pdcs: 135 nCPM
plasma cells: 113 nCPM
neutrophil progenitors: 109 nCPM
esophageal suprabasal cells: 100 nCPM
breast lactating cells: 100 nCPM

Immune cell

plasmacytoid DC: 69 nTPM
eosinophil: 52 nTPM
neutrophil: 41 nTPM
myeloid DC: 33 nTPM
NK-cell: 32 nTPM
classical monocyte: 31 nTPM

Brain region

cerebellum: 21 nTPM
medulla oblongata: 18 nTPM
cerebral cortex: 17 nTPM
thalamus: 15 nTPM
amygdala: 15 nTPM
midbrain: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0.02
gnomAD missense Z: 0.93
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

mitochondrion-mitochondrion outer membrane tether activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRABD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRABD as an antibody target. Whether an autoantibody or antibody against TRABD could matter depends on whether native TRABD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRABD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRABD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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