TPD52L3
Tumor protein D55
Also known as: D55, NYD-SP25, TPD55, TPD55_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96J77
- Gene
- TPD52L3
- Ensembl
- ENSG00000170777
- Chromosome
- 9
- Canonical length
- 140 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
This gene encodes a member of the tumor protein D52-like family of proteins. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. The encoded protein may play a role in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Canonical amino-acid sequenceUniProt
140 residues, UniProt reviewed canonical sequence.
>Q96J77|TPD52L3
1 MPHARTETSV GTYESHSTSE LEDLTEPEQR ELKTKLTKLE AEIVTLRHVL AAKERRCGEL
61 KRKLGLTALV GLRQNLSKSW LDVQVSNTYV KQKTSAALST MGTLICRKLG GVKKSATFRS
121 FEGLMGTIKS KVSGGKRAWPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TPD52L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 144 nTPM
Expression across tissuesHPA
Tissue
- testis: 144 nTPM
- prostate: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- late spermatids: 1,988 nCPM
- late primary spermatocytes: 856 nCPM
- early spermatids: 590 nCPM
- early primary spermatocytes: 39 nCPM
- sertoli cells: 7 nCPM
- leydig cells: 5.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
- white matter: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.55
- gnomAD pLI
- 0.2
- gnomAD missense Z
- -1.23
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TPD52L3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TPD52L3 as an antibody target. Whether an autoantibody or antibody against TPD52L3 could matter depends on whether native TPD52L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TPD52L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TPD52L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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