MAL2
Protein MAL2
Also known as: MAL2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q969L2
- Gene
- MAL2
- Ensembl
- ENSG00000147676
- Chromosome
- 8
- Canonical length
- 176 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
176 residues, UniProt reviewed canonical sequence.
>Q969L2|MAL2
1 MSAGGASVPP PPNPAVSFPP PRVTLPAGPD ILRTYSGAFV CLEILFGGLV WILVASSNVP
61 LPLLQGWVMF VSVTAFFFSL LFLGMFLSGM VAQIDANWNF LDFAYHFTVF VFYFGAFLLE
121 AAATSLHDLH CNTTITGQPL LSDNQYNINV AASIFAFMTT ACYGCSLGLA LRRWRPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MAL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 239 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 239 nTPM
- thyroid gland: 138 nTPM
- stomach: 130 nTPM
- skin: 114 nTPM
- vagina: 99 nTPM
- colon: 97 nTPM
Single-cell type
- esophageal apical cells: 2,981 nCPM
- esophageal suprabasal cells: 1,252 nCPM
- ocular epithelial cells: 894 nCPM
- suprabasal keratinocytes: 824 nCPM
- gastric progenitor cells: 570 nCPM
- foveolar cells: 564 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 77 nTPM
- hippocampal formation: 61 nTPM
- hypothalamus: 61 nTPM
- cerebellum: 61 nTPM
- basal ganglia: 54 nTPM
- thalamus: 45 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.1
- gnomAD pLI
- 0.14
- gnomAD missense Z
- 0.5
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MAL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MAL2 as an antibody target. Whether an autoantibody or antibody against MAL2 could matter depends on whether native MAL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MAL2 is annotated at the cell surface, where native MAL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MAL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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