Seroatlas · Human Serome Atlas

SCN2B

Sodium channel regulatory subunit beta-2

Also known as: SCN2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60939
Gene
SCN2B
Ensembl
ENSG00000149575
Chromosome
11
Canonical length
215 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>O60939|SCN2B
     1  MHRDAWLPRP AFSLTGLSLF FSLVPPGRSM EVTVPATLNV LNGSDARLPC TFNSCYTVNH
    61  KQFSLNWTYQ ECNNCSEEMF LQFRMKIINL KLERFQDRVE FSGNPSKYDV SVMLRNVQPE
   121  DEGIYNCYIM NPPDRHRGHG KIHLQVLMEE PPERDSTVAV IVGASVGGFL AVVILVLMVV
   181  KCVRRKKEQK LSTDDLKTEE EGKTDGEGNP DDGAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCN2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 48 nTPM
  • cerebral cortex: 38 nTPM
  • basal ganglia: 32 nTPM
  • hippocampal formation: 17 nTPM
  • hypothalamus: 17 nTPM
  • amygdala: 16 nTPM

Single-cell type

  • brain inhibitory neurons: 34 nCPM
  • other brain neurons: 28 nCPM
  • retinal amacrine cells: 28 nCPM
  • brain excitatory neurons: 28 nCPM
  • retinal ganglion cells: 16 nCPM
  • retinal horizontal cells: 10 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • neutrophil: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 96 nTPM
  • white matter: 70 nTPM
  • hippocampal formation: 69 nTPM
  • basal ganglia: 68 nTPM
  • thalamus: 67 nTPM
  • amygdala: 57 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SCN2B.

Disease | AllUniProt

Conditions SCN2B is implicated in, by any mechanism.

  • Atrial fibrillation, familial, 14 (ATFB14) MIM:615378

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.4
gnomAD pLI
0
gnomAD missense Z
0.32
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCN2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCN2B as an antibody target. Whether an autoantibody or antibody against SCN2B could matter depends on whether native SCN2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCN2B is annotated at the cell surface, where native SCN2B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SCN2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCN2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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