Seroatlas · Human Serome Atlas

TRPA1

Transient receptor potential cation channel subfamily A member 1

Also known as: ANKTM1, TRPA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75762
Gene
TRPA1
Ensembl
ENSG00000104321
Chromosome
8
Canonical length
1119 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Quaternary structure
Homotetramer

OverviewNCBI Gene

The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1119 residues, UniProt reviewed canonical sequence.

>O75762|TRPA1
     1  MKRSLRKMWR PGEKKEPQGV VYEDVPDDTE DFKESLKVVF EGSAYGLQNF NKQKKLKRCD
    61  DMDTFFLHYA AAEGQIELME KITRDSSLEV LHEMDDYGNT PLHCAVEKNQ IESVKFLLSR
   121  GANPNLRNFN MMAPLHIAVQ GMNNEVMKVL LEHRTIDVNL EGENGNTAVI IACTTNNSEA
   181  LQILLKKGAK PCKSNKWGCF PIHQAAFSGS KECMEIILRF GEEHGYSRQL HINFMNNGKA
   241  TPLHLAVQNG DLEMIKMCLD NGAQIDPVEK GRCTAIHFAA TQGATEIVKL MISSYSGSVD
   301  IVNTTDGCHE TMLHRASLFD HHELADYLIS VGADINKIDS EGRSPLILAT ASASWNIVNL
   361  LLSKGAQVDI KDNFGRNFLH LTVQQPYGLK NLRPEFMQMQ QIKELVMDED NDGCTPLHYA
   421  CRQGGPGSVN NLLGFNVSIH SKSKDKKSPL HFAASYGRIN TCQRLLQDIS DTRLLNEGDL
   481  HGMTPLHLAA KNGHDKVVQL LLKKGALFLS DHNGWTALHH ASMGGYTQTM KVILDTNLKC
   541  TDRLDEDGNT ALHFAAREGH AKAVALLLSH NADIVLNKQQ ASFLHLALHN KRKEVVLTII
   601  RSKRWDECLK IFSHNSPGNK CPITEMIEYL PECMKVLLDF CMLHSTEDKS CRDYYIEYNF
   661  KYLQCPLEFT KKTPTQDVIY EPLTALNAMV QNNRIELLNH PVCKEYLLMK WLAYGFRAHM
   721  MNLGSYCLGL IPMTILVVNI KPGMAFNSTG IINETSDHSE ILDTTNSYLI KTCMILVFLS
   781  SIFGYCKEAG QIFQQKRNYF MDISNVLEWI IYTTGIIFVL PLFVEIPAHL QWQCGAIAVY
   841  FYWMNFLLYL QRFENCGIFI VMLEVILKTL LRSTVVFIFL LLAFGLSFYI LLNLQDPFSS
   901  PLLSIIQTFS MMLGDINYRE SFLEPYLRNE LAHPVLSFAQ LVSFTIFVPI VLMNLLIGLA
   961  VGDIAEVQKH ASLKRIAMQV ELHTSLEKKL PLWFLRKVDQ KSTIVYPNKP RSGGMLFHIF
  1021  CFLFCTGEIR QEIPNADKSL EMEILKQKYR LKDLTFLLEK QHELIKLIIQ KMEIISETED
  1081  DDSHCSFQDR FKKEQMEQRN SRWNTVLRAV KAKTHHLEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRPA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 26 nTPM
  • stomach: 9.7 nTPM
  • rectum: 8.6 nTPM
  • colon: 7.4 nTPM
  • small intestine: 7 nTPM
  • gallbladder: 6.5 nTPM

Single-cell type

  • goblet cells: 74 nCPM
  • fibroblasts: 59 nCPM
  • myosatellite cells: 54 nCPM
  • adipocytes: 49 nCPM
  • fibro-adipogenic progenitors: 40 nCPM
  • pericytes: 24 nCPM

Immune cell

  • memory CD8 T-cell: 0.4 nTPM
  • MAIT T-cell: 0.2 nTPM
  • non-classical monocyte: 0.2 nTPM
  • T-reg: 0.2 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • hippocampal formation: 2.5 nTPM
  • cerebral cortex: 2.3 nTPM
  • white matter: 1.3 nTPM
  • medulla oblongata: 1.2 nTPM
  • amygdala: 1.1 nTPM
  • basal ganglia: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRPA1.

Disease | AllUniProt

Conditions TRPA1 is implicated in, by any mechanism.

  • Episodic pain syndrome, familial, 1 (FEPS1) MIM:615040

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 251 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Familial episodic pain syndrome with predominantly upper body involvement

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
0.04
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRPA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRPA1 as an antibody target. Whether an autoantibody or antibody against TRPA1 could matter depends on whether native TRPA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRPA1 is annotated at the cell surface, where native TRPA1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRPA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRPA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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