Seroatlas · Human Serome Atlas

GGT7

Glutathione hydrolase 7

Also known as: D20S101, dJ18C9.2, GGT7_HUMAN, GGTL3, GGTL5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJ14
Gene: GGT7
Ensembl: ENSG00000131067
Chromosome: 20
Canonical length: 662 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

662 residues, UniProt reviewed canonical sequence.

>Q9UJ14|GGT7
     1  MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAAP LRGRKDEDAF LGDPDTDPDS
    61  FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAAAEC SCRQDGLTVI VTACLTFATG
   121  VTVALVMQIY FGDPQIFQQG AVVTDAARCT SLGIEVLSKQ GSSVDAAVAA ALCLGIVAPH
   181  SSGLGGGGVM LVHDIRRNES HLIDFRESAP GALREETLQR SWETKPGLLV GVPGMVKGLH
   241  EAHQLYGRLP WSQVLAFAAA VAQDGFNVTH DLARALAEQL PPNMSERFRE TFLPSGRPPL
   301  PGSLLHRPDL AEVLDVLGTS GPAAFYAGGN LTLEMVAEAQ HAGGVITEED FSNYSALVEK
   361  PVCGVYRGHL VLSPPPPHTG PALISALNIL EGFNLTSLVS REQALHWVAE TLKIALALAS
   421  RLGDPVYDST ITESMDDMLS KVEAAYLRGH INDSQAAPAP LLPVYELDGA PTAAQVLIMG
   481  PDDFIVAMVS SLNQPFGSGL ITPSGILLNS QMLDFSWPNR TANHSAPSLE NSVQPGKRPL
   541  SFLLPTVVRP AEGLCGTYLA LGANGAARGL SGLTQVLLNV LTLNRNLSDS LARGRLHPDL
   601  QSNLLQVDSE FTEEEIEFLE ARGHHVEKVD VLSWVHGSRR TNNFIIAVKD PRSPDAAGAT
   661  IL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GGT7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 80 nTPM
skeletal muscle: 64 nTPM
choroid plexus: 54 nTPM
cerebral cortex: 42 nTPM
pituitary gland: 39 nTPM
hypothalamus: 30 nTPM

Single-cell type

retinal ganglion cells: 158 nCPM
myonuclei: 133 nCPM
retinal amacrine cells: 124 nCPM
choroid plexus epithelial cells: 115 nCPM
pituitary stem cells: 98 nCPM
retinal bipolar cells: 93 nCPM

Immune cell

naive CD4 T-cell: 12 nTPM
naive CD8 T-cell: 8.2 nTPM
gdT-cell: 7 nTPM
memory B-cell: 6.1 nTPM
memory CD4 T-cell: 5.8 nTPM
naive B-cell: 5.4 nTPM

Brain region

choroid plexus: 114 nTPM
cerebral cortex: 91 nTPM
cerebellum: 91 nTPM
hippocampal formation: 82 nTPM
basal ganglia: 78 nTPM
white matter: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
gnomAD missense Z: 2.3
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GGT7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GGT7 as an antibody target. Whether an autoantibody or antibody against GGT7 could matter depends on whether native GGT7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GGT7 is annotated at the cell surface, where native GGT7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GGT7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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