Seroatlas · Human Serome Atlas

TIMM29

Mitochondrial import inner membrane translocase subunit Tim29

Also known as: C19orf52, TIM29, TIM29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSF4
Gene: TIMM29
Ensembl: ENSG00000142444
Chromosome: 19
Canonical length: 260 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables protein transporter activity. Involved in protein insertion into mitochondrial inner membrane. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of TIM22 mitochondrial import inner membrane insertion complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>Q9BSF4|TIMM29
     1  MAAAALRRFW SRRRAEAGDA VVAKPGVWAR LGSWARALLR DYAEACRDAS AEARARPGRA
    61  AVYVGLLGGA AACFTLAPSE GAFEEALLEA SGTLLLLAPA TRNRESEAFV QRLLWLRGRG
   121  RLRYVNLGLC SLVYEAPFDA QASLYQARCR YLQPRWTDFP GRVLDVGFVG RWWVLGAWMR
   181  DCDINDDEFL HLPAHLRVVG PQQLHSETNE RLFDEKYKPV VLTDDQVDQA LWEEQVLQKE
   241  KKDRLALSQA HSLVQAEAPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIMM29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 24 nTPM
esophagus: 15 nTPM
skin: 14 nTPM
heart muscle: 14 nTPM
testis: 13 nTPM
liver: 13 nTPM

Single-cell type

early primary spermatocytes: 124 nCPM
esophageal apical cells: 60 nCPM
differentiating spermatogonia: 49 nCPM
syncytiotrophoblasts: 46 nCPM
cytotrophoblasts: 44 nCPM
migrating cytotrophoblasts: 40 nCPM

Immune cell

memory B-cell: 18 nTPM
naive B-cell: 15 nTPM
T-reg: 13 nTPM
memory CD8 T-cell: 12 nTPM
NK-cell: 11 nTPM
plasmacytoid DC: 11 nTPM

Brain region

medulla oblongata: 19 nTPM
cerebral cortex: 18 nTPM
hippocampal formation: 17 nTPM
amygdala: 16 nTPM
midbrain: 16 nTPM
thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
DepMap mean gene effect: -0.62
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Mitochondrial import inner membrane translocase subunit Tim29
Translocase of the Inner Mitochondrial membrane 29

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TIMM29 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIMM29 as an antibody target. Whether an autoantibody or antibody against TIMM29 could matter depends on whether native TIMM29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIMM29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIMM29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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